Compound E inhibits the growth of T47D and MCF-7 cell lines by less than 50% at a 50 μM concentration[1].
体外研究
Compound E inhibits the growth of T47D and MCF-7 cell lines by less than 50% at a 50 μM concentration[1].
Compound E 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MT-1 cells
5μM
24 h
Compound E induced caspase-9 and caspase-3 activities.
Leukemia. 2015 Mar;29(3):556-66
MT-1 cells
10μM
48 h
Compound E induced apoptosis in MT-1 cells.
Leukemia. 2015 Mar;29(3):556-66
IMR-32 neuroblastoma cells
10 μM
5 days
To evaluate the effects of GSIs alone or in combination with 13-cis retinoic acid (RA) on neuroblastoma cell growth, differentiation, and migration. Results showed that GSIs alone induced complete cell growth arrest, promoted neuronal differentiation, and significantly reduced cell motility. The combination with 13-cis RA enhanced these effects.
Neuro Oncol. 2010 Dec;12(12):1231-43
SH-SY5Y neuroblastoma cells
10 μM
5 days
To evaluate the effects of GSIs alone or in combination with 13-cis retinoic acid (RA) on neuroblastoma cell growth, differentiation, and migration. Results showed that GSIs alone induced complete cell growth arrest, promoted neuronal differentiation, and significantly reduced cell motility. The combination with 13-cis RA enhanced these effects.
Neuro Oncol. 2010 Dec;12(12):1231-43
MT-1 cells
0, 0.1, 0.5, 1.25, 2.5, 5 or 10μM
48 h
Compound E suppressed MT-1 cell proliferation in a dose-dependent manner.
Leukemia. 2015 Mar;29(3):556-66
HK-2 cells
100 nM
72 h
To evaluate the effects of Compound E on TGF-β1 and fibronectin secretion in HK-2 cells. Results showed that Compound E alone significantly increased TGF-β1 and fibronectin secretion, similar to the effects of high albumin concentrations.
Br J Pharmacol. 2013 Jul;169(6):1239-51
Bovine polymorphonuclear neutrophils (PMN)
20 nM
30 min
Inhibition of Notch signaling to assess its effect on C. parvum-induced NETosis. Results showed that Compound E significantly reduced NET formation.
Biology (Basel). 2022 Mar 14;11(3):442
bovine monocytes
20 nM
30 min
Inhibition of Notch signaling pathway, reducing C. parvum-induced METosis
Biology (Basel). 2023 Jul 5;12(7):961
Compound E 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
NOG mice
MT-1 adult T-cell leukemia model
Subcutaneous osmotic pump
10μmol/Kg
Continuous administration for 28 days
Compound E alone or in combination with Bortezomib and Romidepsin significantly inhibited tumor growth and prolonged the survival of leukemia-bearing mice.
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