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Cinobufotalin is one of the bufadienolides prepared from toad venom with anticancer activity.
Cinobufotalin/华蟾毒它灵 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HCC-LM3
655.4 nM
Determine the IC50 value of Cinobufotalin on HCC-LM3 cells
Int J Biol Sci. 2022 Mar 21;18(6):2553-2567
SMMC-7721
480.5 nM
Determine the IC50 value of Cinobufotalin on SMMC-7721 cells
Int J Biol Sci. 2022 Mar 21;18(6):2553-2567
SV-HUC-1 cells
0.623 μM
48 h
To evaluate the effect of cinobufotalin on normal uroepithelial cells, results showed that cinobufotalin had minimal toxicity on SV-HUC-1 cells.
Cell Death Dis. 2024 Dec 18;15(12):908
RT4 cells
0.169 μM
48 h
To evaluate the effect of cinobufotalin on the viability and proliferation of bladder cancer cells, results showed that cinobufotalin significantly inhibited the viability and proliferation of RT4 cells.
Cell Death Dis. 2024 Dec 18;15(12):908
RT112 cells
0.121 μM
48 h
To evaluate the effect of cinobufotalin on the viability and proliferation of bladder cancer cells, results showed that cinobufotalin significantly inhibited the viability and proliferation of RT112 cells.
Cell Death Dis. 2024 Dec 18;15(12):908
SPC-A1 cells
500 nM
48 h
Cinobufotalin decreased DDP resistance and attenuated cell migration and invasion in SPC-A1 cells.
Acta Pharmacol Sin. 2022 Oct;43(10):2687-2695
A549 cells
500 nM
48 h
Cinobufotalin decreased DDP resistance and attenuated cell migration and invasion in A549 cells.
Acta Pharmacol Sin. 2022 Oct;43(10):2687-2695
MDCK-MDR1 cells
5 and 20 μM
2 h
Evaluate the effect of P-gp on cinobufotalin uptake. Results showed that the intracellular accumulation of cinobufotalin in MDCK-MDR1 cells was significantly lower than that in MDCK II cells, but significantly increased after adding verapamil.
Front Pharmacol. 2019 May 17;10:521
MDCK II cells
5 and 20 μM
2 h
Evaluate the effect of P-gp on cinobufotalin uptake. Results showed that the intracellular accumulation of cinobufotalin in MDCK II cells was significantly higher than that in MDCK-MDR1 cells.
Front Pharmacol. 2019 May 17;10:521
HepG2
0-0.8 μM
48 h
To evaluate the effect of Cinobufotalin on the viability of HepG2 cells, results showed that Cinobufotalin inhibited HepG2 cell viability in a concentration-dependent manner.
Front Oncol. 2024 Oct 16;14:1438306
LM3
0-0.8 μM
48 h
To evaluate the effect of Cinobufotalin on the viability of LM3 cells, results showed that Cinobufotalin inhibited LM3 cell viability in a concentration-dependent manner.
Front Oncol. 2024 Oct 16;14:1438306
Huh-7
0-0.8 μM
48 h
To evaluate the effect of Cinobufotalin on the viability of Huh-7 cells, results showed that Cinobufotalin inhibited Huh-7 cell viability in a concentration-dependent manner.
Front Oncol. 2024 Oct 16;14:1438306
Hep3b
0-0.8 μM
48 h
To evaluate the effect of Cinobufotalin on the viability of Hep3b cells, results showed that Cinobufotalin inhibited Hep3b cell viability in a concentration-dependent manner.
Front Oncol. 2024 Oct 16;14:1438306
5-8F cells
0.25, 0.5 μM
48 h
Cinobufotalin significantly suppressed EBV-miR-BART22-induced DDP chemoresistance by upregulating MAP2K4 to suppress MYH9/GSK3β/β-catenin and its downstream tumor stemness and EMT signals in NPC.
EBioMedicine. 2019 Oct;48:386-404
HONE1-EBV+ cells
0.25, 0.5 μM
48 h
Cinobufotalin significantly suppressed EBV-miR-BART22-induced DDP chemoresistance by upregulating MAP2K4 to suppress MYH9/GSK3β/β-catenin and its downstream tumor stemness and EMT signals in NPC.
EBioMedicine. 2019 Oct;48:386-404
5-8F cells
750 nM
48 h
Cinobufotalin significantly inhibited the formation of tumorspheres, invasion, and migration in FOXO1-overexpressing 5-8F cells and reduced MYH9 expression levels.
Signal Transduct Target Ther. 2019 Nov 18;4:48
HONE1-EBV+ cells
750 nM
48 h
Cinobufotalin significantly inhibited the formation of tumorspheres, invasion, and migration in FOXO1-overexpressing HONE1-EBV+ cells and reduced MYH9 expression levels.
Signal Transduct Target Ther. 2019 Nov 18;4:48
Cinobufotalin/华蟾毒它灵 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
BALB/c-nu mice
Subcutaneous xenograft mouse model
Intraperitoneal injection
4 mg/kg, 8 mg/kg, 12 mg/kg, 20 mg/kg
Every three days for three weeks
Evaluate the toxicity and effectiveness of Cinobufotalin
Int J Biol Sci. 2022 Mar 21;18(6):2553-2567
BALB/c nude mice
RT112 xenograft bladder cancer model
Intraperitoneal injection
1 mg/kg and 5 mg/kg
Once daily for 22 days
To evaluate the antitumor activity of cinobufotalin in vivo, results showed that cinobufotalin significantly suppressed tumor growth with no obvious toxicity.
Cell Death Dis. 2024 Dec 18;15(12):908
BALB/c-nu mice
Lung adenocarcinoma xenograft model
Intraperitoneal injection
4 mg/kg
Every 4 days for 4 days
Cinobufotalin combined with DDP significantly prolonged the survival time of mice and inhibited tumor growth.
Acta Pharmacol Sin. 2022 Oct;43(10):2687-2695
BALB/c nude mice
Liver cancer xenograft model
Intraperitoneal injection
2 mg/kg
Every two days for 27 days
Evaluate the inhibitory effect of Cinobufotalin Injection on liver cancer growth in vivo, results showed that the tumor growth rates in the treatment groups were significantly lower than those in the control groups
Drug Des Devel Ther. 2024 Apr 23;18:1321-1338
Sprague Dawley rats
DEN-induced hepatocellular carcinoma model
Intravenous injection
2.5 mg/kg
Single dose
Compare the pharmacokinetic behaviors of cinobufotalin between normal and DEN-injured rats. Results showed that the AUC and liver concentration of cinobufotalin in DEN-injured rats were significantly lower than those in normal rats.
Front Pharmacol. 2019 May 17;10:521
Nude mice
Subcutaneous xenograft mouse model and pulmonary metastasis model
Intraperitoneal injection
8 mg/kg
Once every day for 14 days
To evaluate the inhibitory effect of Cinobufotalin on the proliferation and metastasis of HCC cells in nude mice, results showed that Cinobufotalin significantly inhibited tumor growth and lung metastasis.
China, Liaoning
... 展开 >>
The First Affiliated Hospital of Dalian Medical University
Not yet recruiting
Dalian, Liaoning, China, 116000
Contact: Xiaonan Cui +8618098876725 cxn23@sina.com
Liaoning Cancer Hospital
Not yet recruiting
Shenyang, Liaoning, China, 110000
Contact: Rui Zhang +8613898872185 zzzrrr1234@sina.com 收起 <<
China, Liaoning
... 展开 >>
The First Affiliated Hospital of Dalian Medical University
Not yet recruiting
Dalian, Liaoning, China, 116000
Contact: Xiaonan Cui +8618098876725 cxn23@sina.com
Liaoning Cancer Hospital
Not yet recruiting
Shenyang, Liaoning, China, 110000
Contact: Rui Zhang +8613898872185 zzzrrr1234@sina.com 收起 <<
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