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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
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Accessible (Haz class 3, 4, 5 or 8), International
CNQX disodium (FG9065 disodium), a potent and competitive AMPA/kainate receptor antagonist, displays IC50s of 0.3 μM and 1.5 μM, respectively, functioning as a competitive non-NMDA receptor antagonist[1]. CNQX disodium suppresses the expression of fear-potentiated startle in rats[5].
体内研究
CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) diminishes the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval[4].
Bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min before a retention test partially impedes the expression of stepdown inhibitory avoidance in rats 24 h after training. Complete blockade is achieved with a dose of 0.5 μg[5].
体外研究
CNQX disodium (FG9065 disodium; 2-5 μM) reversibly inhibits the Schaffer collateral and mossy fiber excitatory postsynaptic potential (EPSP) while preserving fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
CNQX disodium (1-5 μM) induces a selective and dose-dependent decrease in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].
CNQX significantly reduced the spontaneous discharge frequency of ARC neurons in inflamed rats from (2.17±0.25) Hz to (1.32±0.15) Hz (P<0.01), indicating the critical role of non-NMDA receptors in inflammation-induced neuronal activation.
Acta Pharmacol Sin. 2011 Feb;32(2):160-6
Immature rat spinal cord preparations
4, 10, 25 μM
25-30 min
To measure the antagonism of depolarizations induced by NMDA, kainate, or quisqualate by CNQX. In the presence of 0.75 mM Mg2+, pA2 values were 4.62 ± 0.05 (NMDA), 5.79 ± 0.01 (kainate), 5.59 ± 0.05 (quisqualate).
Br J Pharmacol. 1990 Aug;100(4):850-4
Mature rat spinal cord preparations
1.0 μM
To compare the depressant effects of CNQX and kynurenate on transmission from low threshold myelinated primary afferents. The EC50 for CNQX-induced depression of the monosynaptic ventral root reflex was 1.0 μM.
Br J Pharmacol. 1990 Aug;100(4):850-4
rat striatal neurons
10 μM
To investigate the inhibitory effect of CNQX on synaptic potentials in striatal neurons, showing that CNQX reversibly blocks the depolarizing synaptic potential evoked by stimulation of corticostriatal fibers.
J Physiol. 1991 Nov;443:533-53
HEK293 cells
30 µM
5 seconds
To study the inhibitory effect of CNQX on GluN1a-3A NMDAR
Sci Adv. 2024 Apr 12;10(15):eadl5952
CNQX disodium 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
L5-L6 spinal nerve ligation (SNL) model
Intra-LC injection
0.3 μg
Single injection, behavioral testing performed 15 minutes post-injection
CNQX blocked the antihypersensitivity effect of intra-LC gabapentin
Anesthesiology. 2008 Dec;109(6):1077-84
Rats
Water maze test
Bilateral intra-LHb infusion
267 ng/side
Single injection, behavioral testing performed 15 minutes post-injection
To investigate the role of LHb in encoding and retrieval of spatial memory. CNQX infusion prevented encoding and retrieval but not consolidation of spatial information.
Neuropsychopharmacology. 2015 Nov;40(12):2843-51
Adult Brown-Norway rats
Optic nerve transection model
Intravitreal injection
0.2 mM
Single injection
CNQX substantially reduced the nSTR and also reduced the scotopic b-wave by ～40%.
J Physiol. 2004 Feb 15;555(Pt 1):153-73
Mice
Awake mice
Pressure injection
100 μM
10 minutes
CNQX reduced the frequency and area of hotspot events, indicating that hotspot signals are generated primarily by excitatory synaptic input and stochastic voltage fluctuations within the dendrite
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