There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Bleomycin Sulfate is a glycopeptide antitumor antibiotic with antineoplastic efficacy[1]. Bleomycin sulfate treatment (3.5-4.0 mg/kg; intra-tracheal) on day 0, body weights decrease by day 4 then increases by Day 7 through the end of the study. Intra-tracheal bleomycin produced a statistically significant increase in lung hydroxyproline levels as well as increase in right caudal lung lobe mass[2]. Bleomycin sulfate (intratracheally; 2.5 mg/kg; 1.25 mg/ml, approximately 50 µl per mouse) induces pulmonary fibrosis in male C57BL/6 mice (8 weeks old, average weight approximately 24.5 g) [3].
体外研究
Bleomycin sulfate (BLM) has been selected as the most well-studied micronucleus (MN) inducer in human lymphocytes with different mechanisms of genotoxicity. The most common types of Bleomycin-induced DNA damage are single and double strand breaks and single depyrimidine/dehydropyrimidine sites. At the same time Bleomycin is a true radiomimetic compound, almost exactly resembling the genetic effects of ionising radiation [4].
The IC50 value of Bleomycin sulfate against the UT-SCC-19A cell line was 4.0±1.3 nM. Both UT-SCC-12A and UT-SCC-12B were more resistant to Bleomycin sulfate (BLM); IC50 values were 14.2±2.8 nM and 13.0±1.1 nM, respectively [5].
Bleomycin sulfate (50, 100 μM; 24, 48 h) induced pulmonary fibrosis in RLE-6TN cells (50 μM) and A549 cells (100 μM) [6].
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