货号:A1364961
同义名:
MEDI-563(anti-IL5RA ); BIW-8405(anti-IL5RA )
Benralizumab是一种人源化IgG1单克隆抗体,通过与IL-5Ra结合来耗竭嗜酸性粒细胞。Benralizumab具有用于重度嗜酸性哮喘研究的潜力。


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| 蛋白种属 | Human |
| 交叉反应性 | Human,Mouse,Rat,Rabbit |
| Isotype | IgG1-Kappa |
| 内毒素 | < 0.001EU/μg, determined by LAL method. |
| 纯化方法 | Purified, Protein A, affinity column |
| 稀释缓冲液 | Sterile PBS or 0.9% saline for reconstitution/dilution. It is recommended to use the reconstituted/diluted product within one month. |
| Concentration | Treated Time | Description | References | |
| Macrophages | 10 nM | 6 h | Evaluate macrophage phagocytosis of eosinophils, showing benralizumab enhanced macrophage phagocytic activity and cytotoxicity | Eur Respir J. 2022 Mar 3;59(3):2004306 |
| Natural Killer (NK) cells | 10 nM | 6 h | Assess NK cell activation and cytotoxicity, showing benralizumab significantly increased CD137 and LAMP-1 expression and promoted NK cell degranulation | Eur Respir J. 2022 Mar 3;59(3):2004306 |
| Eosinophils | 10 nM | 6 h | Evaluate eosinophil apoptosis, demonstrated by PO-PRO-1 staining, showing benralizumab significantly enhanced eosinophil death | Eur Respir J. 2022 Mar 3;59(3):2004306 |
| CAS号 | 1044511-01-4 |
| 分子量 | 146.06 kDa |
| SMILES Code | NONE |
| 别名 | MEDI-563(anti-IL5RA ); BIW-8405(anti-IL5RA ); Benralizumab(anti-IL5RA ) |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:24个月 |
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