Detect S746-phosphorylation of Exo1 under replication stress
Mol Cell. 2019 Jun 20;74(6):1123-1137. e6
Human cell extract
100–200 μM
60 min
Inhibition of cccDNA formation
Nat Microbiol. 2020 May;5(5):715-726
U2OS cells
0.5 μM
4 h
To investigate the effect of Aphidicolin on ionizing radiation-induced γH2AX foci formation, results showed that APH reduced the proportion of γH2AX-positive cells.
Nucleic Acids Res. 2012 Aug;40(14):6585-94
AA8 cells
0.5 μM
4 h
To study the effect of Aphidicolin on ionizing radiation-induced RAD51 foci formation, results showed that APH significantly decreased the proportion of RAD51-positive cells.
Nucleic Acids Res. 2012 Aug;40(14):6585-94
SPD8 cells
0.5 μM
4 h
To investigate the effect of Aphidicolin on ionizing radiation-induced homologous recombination repair, results showed that APH significantly reduced IR-induced recombination frequencies.
Nucleic Acids Res. 2012 Aug;40(14):6585-94
embryonic mouse submandibular gland cells
500 ng/ml
24 h
Aphidicolin inhibited the growth of embryonic submandibular glands by interfering with DNA replication, with effects comparable to Barasertib
Cell Death Discov. 2021 Jan 18;7(1):16
DT40 cells
5 μM
1 hour
Inhibits DNA polymerase activity, reduces collision between replication forks and Top1-cc, thereby decreasing CPT sensitivity and Top1 degradation
J Biol Chem. 2014 Apr 18;289(16):11374-11384
Chinese hamster lung fibroblast cell line GMA32
0.3, 0.5 and 0.8 µg/ml
20.5 h
To evaluate the effect of Aphidicolin on chromosome breaks, results showed that Aphidicolin induced chromosome breaks in the GNAI3–GNAT2 region
Nucleic Acids Res. 2000 Dec 1;28(23):4805-13
HPV31 and HPV18 cells
4 μM
48 h
To study the effect of Aphidicolin on different HPV genotypes, results showed that Aphidicolin significantly reduced viral genome copy numbers of HPV31 and HPV18.
J Virol. 2013 Apr;87(7):3979-89
W12E cells
4 μM
48 h
To study the effect of Aphidicolin on the stability of HPV16, HPV18, and HPV31 viral genomes, results showed that Aphidicolin significantly reduced viral genome copy numbers.
搜索
