To evaluate the effect of AHI on chondrogenic differentiation of ACSCs, results showed that AHI significantly promoted the expression of cartilage-specific genes (col2a1, acan, sox9) and proteoglycan accumulation.
Bioact Mater. 2022 May 4;19:487-498
Rabbit articular cartilage stem cells (ACSCs)
3 μM
3 days
To evaluate the effect of AHI on the proliferation of ACSCs, results showed that 3 μM concentration had no significant effect on ACSCs proliferation.
Bioact Mater. 2022 May 4;19:487-498
MDA-MB-231 cells
0, 5, 10, 20, 40, 80, 160 µM
24 h
To evaluate the inhibitory effect of AHI on the proliferation of MDA-MB-231 cells. Results showed that AHI significantly inhibited the proliferation of MDA-MB-231 cells.
Front Cell Dev Biol. 2022 Feb 1;9:764481
4T1 cells
0, 5, 10, 20, 40, 80, 160 µM
24 h
To evaluate the inhibitory effect of AHI on the proliferation of 4T1 cells. Results showed that AHI significantly inhibited the proliferation of 4T1 cells.
Front Cell Dev Biol. 2022 Feb 1;9:764481
Anhydroicaritin/脱水淫羊藿素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude mice
MDA-MB-231 xenograft model
Intraperitoneal injection
20 mg/kg
Once every 2 days for 4 weeks
To evaluate the inhibitory effect of AHI on tumor growth. Results showed that AHI significantly inhibited tumor growth and enhanced GPX1 expression, inhibiting EMT markers.
Front Cell Dev Biol. 2022 Feb 1;9:764481
Wistar rats
Diabetes model
Oral
100 mg/kg
Once daily for 12 weeks
To investigate the effect of β-anhydroicaritin on the expression levels of TNF-α and MMP-3 in the periodontal tissue of diabetic rats. Results showed that β-anhydroicaritin significantly reduced the expression levels of TNF-α and MMP-3 in the periodontal tissue of diabetic rats and improved the pathological changes in the periodontal tissue.
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