ABT-751 | E7010 | Microtubule/Tubulin Inhibitor | AmBeed-信号通路专用抑制剂

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ABT-751 {[allProObj[0].p_purity_real_show]}

货号：A110139 同义名： E7010

ABT-751是一种口服生物利用度高的磺酰胺类抗有丝分裂剂，通过与β-微管蛋白的秋水仙碱结合位点结合，阻止微管的聚合，导致细胞周期停滞在G2/M期，最终引发细胞凋亡。

ABT-751 化学结构
CAS号：141430-65-1

ABT-751 3D分子结构
CAS号：141430-65-1

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ABT-751 纯度/质量文件产品仅供科研

货号：A110139 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Nat. Electron., 2025, 8, 66-74. Ambeed. [ A100095 ]; • Adv. Mater., 2025, 2416621. Ambeed. [ A255324 , A420052 ]; • Adv. Mater., 2025, 2410493. Ambeed. [ A838608 ]; • Adv. Mater., 2025, 2420319. Ambeed. [ A106129 ]; 更多 >

ABT-751 生物活性

描述	ABT-751 is a bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.

ABT-751 细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源
A2780 cells		Cytotoxicity assay	48-72 h	Cytotoxicity against human A2780 cells after 48 to 72 hrs by WAT-1 assay, IC50=0.17 μM	21126027
A549 cells		Proliferation assay	24 h	Antiproliferative activity against human A549 cells assessed as growth inhibition after 24 hrs by SRB assay, GI50=1.31 μM	25468039
ACHN cells		Cytotoxicity assay	48 h	Cytotoxicity against human ACHN cells after 48 hrs by MTT assay, IC50=2.13 μM	24835786
DU145 cells		Proliferation assay	24 h	Antiproliferative activity against human DU145 cells assessed as growth inhibition after 24 hrs by SRB assay, GI50=1.81 μM	25468039

ABT-751 动物研究

Dose	Rat: 3 mg/kg - 30 mg/kg^[3] (i.v.) Mice: 75 mg/kg, 100 mg/kg^[4] (p.o.)
Administration	i.v., p.o.

ABT-751 参考文献

[1]Aggarwal C, Somaiah N, et al. Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed? Cancer Biol Ther. 2012 Mar;13(5):247-63. doi: 10.4161/cbt.19594.

[2]Huang SM, Mishina YM, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009 Oct 1;461(7264):614-20.

ABT-751 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.46mL

2.69mL

1.35mL

26.92mL

5.38mL

2.69mL

ABT-751 技术信息

CAS号	141430-65-1
分子式	C₁₈H₁₇N₃O₄S
分子量	371.41
SMILES Code	O=S(C1=CC=C(C=C1)OC)(NC2=CC=CN=C2NC3=CC=C(C=C3)O)=O
MDL No.	MFCD00910291

别名	E7010
运输	蓝冰
InChI Key	URCVCIZFVQDVPM-UHFFFAOYSA-N
Pubchem ID	3035714

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(282.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 4.2 mg/mL clear

PO 0.5% CMC-Na 34 mg/mL suspension

细胞研究

细胞系	浓度	检测类型	检测时间	活性说明	数据源

A2780 cells		Cytotoxicity assay	48-72 h	Cytotoxicity against human A2780 cells after 48 to 72 hrs by WAT-1 assay, IC50=0.17 μM	21126027
A549 cells		Proliferation assay	24 h	Antiproliferative activity against human A549 cells assessed as growth inhibition after 24 hrs by SRB assay, GI50=1.31 μM	25468039
ACHN cells		Cytotoxicity assay	48 h	Cytotoxicity against human ACHN cells after 48 hrs by MTT assay, IC50=2.13 μM	24835786
DU145 cells		Proliferation assay	24 h	Antiproliferative activity against human DU145 cells assessed as growth inhibition after 24 hrs by SRB assay, GI50=1.81 μM	25468039
DU145 cells		Cytotoxicity assay	48 h	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay， GI50=1.81 μM	24835786
H460 cells		Cytotoxicity assay	72 h	Cytotoxicity against human H460 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50=0.2177 μM	24106982
HCT116-C9 cell		Function assay		Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in HCT116-C9 cell line, IC50=0.9 μM	12383017
HCT-15 cell		Proliferation assay		Antiproliferative activity against human colon carcinoma HCT-15 cell line(MDR(-)), IC50=0.34 μM	11425534
HeLa cells		Cytotoxicity assay	48-72 h	Cytotoxicity against human HeLa cells after 48 to 72 hrs by WAT-1 assay, IC50=0.27 μM	21126027
Hep3B cells		Cytotoxicity assay	48 h	Cytotoxicity against human Hep3B cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay, GI50=0.84 μM	26241032
HT-29 cells		Proliferation assay	72 h	Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay, IC50=0.21 μM	23202849
HT-29 cells		Cytotoxicity assay	72 h	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50=0.3387 μM	24106982
HT-29 cells		Cytotoxicity assay	48 h	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay, IC50=1.62 μM	24835786
human A549 cells		Cytotoxicity assay	48 h	Cytotoxicity against human A549 cells after 48 hrs by MTT assay, IC50=1.31 μM	24835786
human A549 cells		Cytotoxicity assay	48 h	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay, GI50=5.33 μM	26241032
human AsPC1 cells		Cytotoxicity assay	48 h	Cytotoxicity against human AsPC1 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay, GI50=4.11 μM	26241032
human HL60 cells		Proliferation assay		Antiproliferative activity against human HL60 cells, IC50=0.34 μM	17276056
human MCF7 cells		Proliferation assay	24 h	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 24 hrs by SRB assay, GI50=1.25 μM	25468039
human PC3 cells		Cytotoxicity assay	48 h	Cytotoxicity against human PC3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay, GI50=0.62 μM	26241032
human SKBR3 cells		Growth inhibition assay	48 h	Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay, IC50=0.74 μM	22850214
HUVEC	100-1000 nM	Function assay	4 h	Induction of vascular disrupting activity in HUVEC assessed as VEGF-induced tube formation at 100 to 1000 nM after 4 hrs by microscopic analysis	24106982
Jurkat cells		Function assay	24 h	Cell cycle arrest in human Jurkat cells assessed as accumulation at G2/M phase after 24 hrs using propidium iodide staining by FACS analysis, IC50=0.16 μM	21126027
KB cells		Cytotoxicity assay	72 h	Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50=0.2513 μM	24106982
KB-7d cells		Cytotoxicity assay	72 h	Cytotoxicity against human KB-7d cells overexpressing MRP assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50=0.205 μM	24106982
KB-S15 cells		Cytotoxicity assay	72 h	Cytotoxicity against human KB-S15 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50=0.206 μM	24106982
KB-VIN10 cells		Cytotoxicity assay	72 h	Cytotoxicity against human KB-VIN10 cells overexpressing P-gp170/MDR assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50=0.227 μM	24106982
MCF7 cells		Cytotoxicity assay	48 h	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay, IC50=1.25 μM	24835786
MDR1 cells		Cytotoxicity assay	48-72 h	Cytotoxicity against human NCI-ADR-RES expressing MDR1 cells after 48 to 72 hrs by WAT-1 assay, IC50=0.29 μM	21126027
MKN45 cells		Cytotoxicity assay	72 h	Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by methylene blue staining-based assay, IC50=0.166 μM	24106982
NCI-H460 cell		Proliferation assay		Antiproliferative activity against human lung carcinoma NCI-H460 cell line (MDR(+)), IC50=0.35 μM	11425534
P388 cell line		Function assay	72 h	Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388 cell line， IC50=0.19 μM	12383017
P388/4.0 r-M cell line		Function assay	72 h	Effective concentration to inhibit cell proliferation by 50% relative to untreated control cell after 72 hr of continuous exposure in P388/4.0 r-M cell line, IC50=15 μM	12383017
SW620 cells		Cytotoxicity assay	48-72 h	Cytotoxicity against human SW620 cells after 48 to 72 hrs by WAT-1 assay, IC50=0.19 μM	21126027

ABT-751 {[allProObj[0].p_purity_real_show]}

ABT-751 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

ABT-751 质控信息

ABT-751 生物活性

ABT-751 细胞研究

ABT-751 动物研究

ABT-751 参考文献

ABT-751 实验方案

ABT-751 技术信息

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ABT-751 {[allProObj[0].p_purity_real_show]}

ABT-751 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

ABT-751 质控信息

ABT-751 生物活性

ABT-751 细胞研究

ABT-751 动物研究

ABT-751 参考文献

ABT-751 实验方案

ABT-751 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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ABT-751 纯度/质量文件产品仅供科研