ABT-751
产品说明书
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同义名 : | E7010 |
| CAS号 : | 141430-65-1 | |
| 货号 : | A110139 | |
| 分子式 : | C18H17N3O4S | |
| 纯度 : | 99%+ | |
| 分子量 : | 371.41 | |
| MDL号 : | MFCD00910291 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(282.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
IP 2% DMSO+2% Tween80+30% PEG300+water 4.2 mg/mL clear PO 0.5% CMC-Na 34 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | ABT-751 is a bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活性说明 | 数据源 |
| A2780 cells | Cytotoxicity assay | 48-72 h | Cytotoxicity against human A2780 cells after 48 to 72 hrs by WAT-1 assay, IC50=0.17 μM | 21126027 | |
| A549 cells | Proliferation assay | 24 h | Antiproliferative activity against human A549 cells assessed as growth inhibition after 24 hrs by SRB assay, GI50=1.31 μM | 25468039 | |
| ACHN cells | Cytotoxicity assay | 48 h | Cytotoxicity against human ACHN cells after 48 hrs by MTT assay, IC50=2.13 μM | 24835786 | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.69mL 0.54mL 0.27mL |
13.46mL 2.69mL 1.35mL |
26.92mL 5.38mL 2.69mL |
| 参考文献 |
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