There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
9-cis-Retinoic acid (ALRT1057), a derivative of vitamin A, acts as a potent agonist for RAR/RXR. It induces apoptosis, regulates the cell cycle, and exhibits anticancer, anti-inflammatory, and neuroprotective properties[1][2][3][4][5].
体内研究
9-cis-Retinoic acid (1 mg/kg; via intravenous injection; daily for 10 days; in male C57BL/6J mice) notably lowers the levels of serum ALT and AST, and mitigates liver necrosis in mice subjected to bile duct ligation (BDL)[3].
体外研究
9-cis-Retinoic acid at concentrations ranging from 1 to 10 μM for 0 to 5 days significantly reduces proliferation in a dose-dependent manner in CA 9-22 and NA cells[1].
After 24 hours of treatment with 9-cis-Retinoic acid at a concentration of 1 μM, PPARγ functional activity increases by over 200% in CA 9-22 and NA aerodigestive cells[1].
9-cis-Retinoic acid treatment leads to the creation of a PPARγ-RXRα heterodimer supershift complex in the nucleus of CA 9-22 cells[1].
9-cis-Retinoic acid hampers the growth and triggers cell death in cutaneous T-cell lymphoma (CTCL) in both dose-dependent and time-dependent manners. Furthermore, this compound prompts cell cycle arrest at the G0/G1 phase by reducing cyclin D1 levels. It markedly diminishes the phosphorylation of JAK1, STAT3, and STAT5, and reduces the expression of Bcl-xL and cyclin D1[2].
9-cis-Retinoic acid/9-顺式视黄酸 细胞实验
Cell Line
Concentration
Treated Time
Description
References
human lymphatic endothelial cells (LECs)
1 µM
24 h
promotes LEC migration
Circulation. 2012 Feb 21;125(7):872-82
human lymphatic endothelial cells (LECs)
1 µM
48 h
promotes LEC proliferation
Circulation. 2012 Feb 21;125(7):872-82
Rat hepatic stellate cells
0.01, 0.1, 1 µM
48, 72, 96 h
To examine the influence of 9-cis retinoic acid on extracellular matrix production and proliferation of activated hepatic stellate cells. Results showed that 9RA increased procollagen I mRNA 1.9-fold but did not affect other matrix proteins.
Gut. 1999 Jul;45(1):134-42
Cultured human mesangial cells (CHMC)
1 μM
24 h
To study the inhibitory effect of 9-cRA on monocyte adhesion to FCS-stimulated CHMC. Results showed that 1 μM 9-cRA significantly inhibited monocyte adhesion.
Br J Pharmacol. 2000 Dec;131(8):1673-83
Cultured human mesangial cells (CHMC)
10 nM
24 h
To study the preventive effect of 9-cRA on H2O2-induced CHMC death. Results showed that 10 nM 9-cRA significantly prevented H2O2-induced cell death.
Br J Pharmacol. 2000 Dec;131(8):1673-83
Cultured human mesangial cells (CHMC)
10 nM to 100 nM
24 h
To study the inhibitory effect of 9-cRA on FCS-induced CHMC proliferation. Results showed that 9-cRA dose-dependently inhibited FCS-induced CHMC proliferation at concentrations ranging from 10 nM to 100 nM.
Br J Pharmacol. 2000 Dec;131(8):1673-83
A818-4 pancreatic adenocarcinoma cells
500 nM
6 days
Did not induce apoptosis
Br J Cancer. 2002 Aug 27;87(5):555-61
AsPc-1 pancreatic adenocarcinoma cells
500 nM
6 days
Induced apoptosis
Br J Cancer. 2002 Aug 27;87(5):555-61
T3M-4 pancreatic adenocarcinoma cells
500 nM
6 days
Induced apoptosis, decreased Bcl-2/Bax ratio
Br J Cancer. 2002 Aug 27;87(5):555-61
BxPc-3 pancreatic adenocarcinoma cells
500 nM
6 days
Induced apoptosis, decreased Bcl-2/Bax ratio
Br J Cancer. 2002 Aug 27;87(5):555-61
9-cis-Retinoic acid/9-顺式视黄酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Nude rats
Human neuroblastoma xenograft model
Oral
2 mg/day or 2.5 mg twice daily
Once or twice daily for 10-12 days
Evaluate the anti-tumor effects and toxicity of 9-cis-retinoic acid. Results showed that 2.5 mg twice daily significantly reduced tumor volume at day 10 but did not significantly reduce tumor weight.
Br J Cancer. 2001 Dec 14;85(12):2004-9
Mice
Mouse tail lymphedema model
Intraperitoneal injection
0.8 mg/kg
Daily for 32 days
9-cisRA significantly reduced tail lymphedema and promoted lymphatic vessel regeneration in mice
搜索
HazMat Fee +
