9-cis-Retinoic acid

产品说明书

Print
Chemical Structure| 5300-03-8 同义名 : Alitretinoin; NSC 659772; Panrexin; Panretin. Panretyn; 9-cis-retinoic acid. Alitretinoin; LGD1057; 9-CRA. 9-cis-RA. ALRT1057; 9-cis RA; Panretin
CAS号 : 5300-03-8
货号 : A1396006
分子式 : C20H28O2
纯度 : 97%
分子量 : 300.44
MDL号 : MFCD00270072
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(83.21 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 9-cis-Retinoic acid (ALRT1057), a derivative of vitamin A, acts as a potent agonist for RAR/RXR. It induces apoptosis, regulates the cell cycle, and exhibits anticancer, anti-inflammatory, and neuroprotective properties[1][2][3][4][5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.64mL

3.33mL

1.66mL

33.28mL

6.66mL

3.33mL
参考文献

[1]Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080.

[2]Hua Yang, et al. Effects of 9-cis-retinoic Acid on the Proliferation and Apoptosis of Cutaneous T-cell Lymphoma Cells. Anticancer Drugs. 2019 Jan;30(1):56-64.

[3]Zhiqing Yuan, et al. 9-cis-retinoic Acid Elevates MRP3 Expression by Inhibiting Sumoylation of RXRα to Alleviate Cholestatic Liver Injury. Biochem Biophys Res Commun. 2018 Sep 3;503(1):188-194.

[4]V M Manzano, et al. Human Renal Mesangial Cells Are a Target for the Anti-Inflammatory Action of 9-cis Retinoic Acid. Br J Pharmacol. 2000 Dec;131(8):1673-83.

[5]Gro H Mathisen, et al. Delayed Translocation of NGFI-B/RXR in Glutamate Stimulated Neurons Allows Late Protection by 9-cis Retinoic Acid. Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5.