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货号 产品名 纯度
A614383 现货 Quercetagetin

Quercetagetin (6-Hydroxyquercetin) 是一种黄酮类化合物,作为一种中度强效且选择性的细胞可渗透 pim-1 激酶抑制剂,IC50 为 0.34 μM。它具有抗炎抗肿瘤活性。

98%
A446749 现货 CX-6258 HCl

CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.

99%+
A797636 现货 NSC756093

97%
A107880 现货 SMI-4a

SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM, modestly potent to Pim-2, does not significantly inhibit any other serine/threonine- or tyrosine-kinases.

99%+
A734369 现货 CX-6258

CX-6258 is a selective and potent Pim inhibitor with IC50 values of 5nM, 25nM and 16nM for Pim-1, Pim-2 and Pim-3 (measured by SAR assay), respectively.

98+%
A310740 现货 SMI-16a

SMI-16a, the PIM1/2 Kinase inhibitor VI, controls the biological activity of PIM1/2. This small molecular inhibitor is primarily used for Phosphorylation & Dephosphorylation applications

99%+
A290934 现货 SGI-1776 free base/SGI-1776 游离碱

SGI-1776 free base is an ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin.

99+%
A178546 现货 AZD-1208

AZD1208 is an orally bioavailable, highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases (IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively) and is used for treating AML.

98%
A735192 现货 PIM447

PIM-447 is pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM)1, 2, and 3 Kinase.

99%+
A1807234 现货 HJ-PI01

99%+
A730268 现货 Pim-1/2 kinase inhibitor 1

97%
A888839 现货 (2R)-Octyl-α-hydroxyglutarate

98%+
A118376 现货 TCS PIM-1 1

TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC50s > 20,000 nM).

99%+
A809668 现货 TP-3654

TP-3654 is a selective Pim kinase inhibitor with Ki values of 5nM, 239nM and 42nM for Pim-1, Pim-2 and Pim-3, respectively, as well as with an average EC50 of 67nM for cellular PIM-1 inhibition in the PIM-1/BAD overexpression system and with moderate potency to FLT3.

99%+
A737829 现货 Hispidulin/高车前素

Hispidulin, a natural product isolated and purified from the herbs of Ambrosia artemisiifolia Linn., is a Pim-1 inhibitor with an IC50 of 2.71 μM.

99%+
A1552530 MNK/PIM-IN-1

98%
A1671181 PIM1-IN-6

98%
A997266 PIM1-IN-2

97%
A1176556 Uzansertib phosphate

99%
A1176740 PIM1-IN-1

99%
产品名 Pim1 Pim2 Pim3 其他靶点 纯度
SMI-4a ++

Pim1, IC50: 17 nM

99%+
SGI-1776 free base ++

Pim1, IC50: 7 nM

+

Pim2, IC50: 363 nM

+

Pim3, IC50: 69 nM

FLT3 99+%
AZD-1208 +++

Pim1, IC50: 0.4 nM

+++

Pim2, IC50: 5 nM

+++

Pim3, IC50: 1.9 nM

98%
CX-6258 HCl +++

Pim1, IC50: 5 nM

+

Pim2, IC50: 25 nM

++

Pim3, IC50: 16 nM

99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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