Ani 9 is selective TMEM16A blocker with IC50 of 77 nM.

NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.

R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.

Selamectin is an avermectin derivative prepared by hydrolysis and oximation of doramectin. Selamectin is a potent nematocide used for the treatment of parasites, which selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission.

ANO1-IN-1是一种选择性 ANO1 通道阻断剂，抑制胶质瘤细胞增殖，IC₅₀ 分别为 2.56 μM 和 15.43 μM，适用于神经胶质瘤的研究。

Afoxolaner是一种针对 γ-氨基丁酸受体（GABA） 和谷氨酸受体 (glutamate receptors)的药物，用于控制寄生虫和螨类，广泛用于兽医学。

Eact is an activator of TMEM16A calcium-activated chloride channel (CaCC) with EC50 of 3 μM. It is also transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM).

T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).

Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

(Rac)-Shikonin是一种天然产物，具有强效的抗肿瘤活性，能够绕过癌症耐药性。

Shikonin is an inhibitor of TMEM16A chloride channel with IC50 of 6.5 μM, it's a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc..

NPPB can act as a blocker of the chloride channel with IC50 of 100 nM-100 µM and inhibitor of cyclooxygenase (IC50 = 8 µM).

Fluralaner (INN) 是一种全身性杀虫剂和杀螨剂，通过强效阻断 GABA 和 L-glutamate氯离子通道发挥作用。

Endovion is a blocker of both VRAC and CaCC with IC50 value around 400nM for blocking swelling-activated anion currents in HEK293 cells.

Fluxametamide 是一种广谱杀虫剂和 GABA 及谷氨酸门控氯离子通道拮抗剂，其对 M. domestica 中的 GABACl 和 GluCl 的 IC50 值分别为 1.95 nM 和 225 nM。

DCPIB是一种体积调节性阴离子通道（VRAC）抑制剂，能有效抑制细胞的钠钾通道和氯电流。它在细胞肿胀和离子通道研究中具有应用潜力。

9-AC is a Cl- transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac IcI.

Adjudin exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.