There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.
体内研究
On dogs treated with fluralaner in a simulated flea-infested environment, the efficacy in controlling fleas exceeds 99% consistently over 12 weeks, without adverse effects observed. Fluralaner ensures complete control over egg production, larval growth, and flea reproduction at concentrations below insecticidal levels. Its oral administration in dogs proves extremely efficient in eradicating fleas in such environments[1].[2].
体外研究
Fluralaner strongly curtails the reproductive capacity of fleas in vitro, halting egg production at as low as 25.0 ng/mL. Although it shows no effect on eggs, it has a larvicidal impact at very low concentrations (6.25 ng/mL)[1].
Fluralaner/氟雷拉纳 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Layer hens
Naturally PRM-infested layer hens
Drinking water
0.5 mg/kg body weight
Twice, 7 days apart
To assess the effects of mite elimination by fluralaner treatment on behavioral welfare parameters and productivity in naturally PRM-infested hens. Results showed >99% efficacy against PRM, improved hen welfare, and enhanced productivity.
Parasit Vectors. 2021 Mar 31;14(1):181
Beagle dogs
Ex vivo feeding model
Oral
25 to 56 mg/kg body weight
Single dose, lasting 12 weeks
Evaluate the efficacy of Fluralaner in preventing the acquisition of Borrelia burgdorferi by ticks. Results showed that Fluralaner's acaricidal efficacy was less than 28% within 12 h, failing to effectively prevent the acquisition of Borrelia burgdorferi.
Microorganisms. 2024 Jan 18;12(1):202
Healthy shaver hens
Healthy shaver hens
Intravenous and transdermal
0.5 mg/kg
Single dose, eggs collected for 28 days (IV) and 40 days (transdermal)
To determine the residue distribution and depletion of fluralaner in eggs and estimate the drug withdrawal interval. Results showed higher fluralaner residues in yolk than albumen, with withdrawal intervals of 7 days (IV) and 81 days (transdermal).
Poult Sci. 2024 Jul;103(7):103843
Cattle
Natural infestation model
Pour-on
2.5 mg/kg BW
Single dose
To evaluate the therapeutic and persistent efficacy of Fluralaner against cattle ectoparasites such as Rhipicephalus microplus, Cochliomyia hominivorax larvae, Dermatobia hominis larvae, and Haematobia irritans. Results showed that Fluralaner's therapeutic efficacy against R. microplus exceeded 98% at 4 days post-treatment, with persistent efficacy (>90%) lasting up to 79 days.
Parasit Vectors. 2023 Sep 26;16(1):336
New Zealand rabbits
Experimental crusted scabies model
Oral
25 mg/kg body weight
Single dose, lasting for 8 weeks
To evaluate the efficacy of Fluralaner in treating crusted scabies, results showed that the Fluralaner-treated group exhibited nearly complete resolution of clinical and parasitological changes
Crusted scabies in a rabbit model: a severe skin disease or more? Parasit Vectors. 2023 Nov 14;16(1):413
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