On dogs treated with fluralaner in a simulated flea-infested environment, the efficacy in controlling fleas exceeds 99% consistently over 12 weeks, without adverse effects observed. Fluralaner ensures complete control over egg production, larval growth, and flea reproduction at concentrations below insecticidal levels. Its oral administration in dogs proves extremely efficient in eradicating fleas in such environments^[1].^[2].

Fluralaner strongly curtails the reproductive capacity of fleas in vitro, halting egg production at as low as 25.0 ng/mL. Although it shows no effect on eggs, it has a larvicidal impact at very low concentrations (6.25 ng/mL)^[1].