Alda-1是一种高效选择性的ALDH2激动剂，能激活野生型ALDH2并恢复ALDH2*2的接近野生型活性。

CVT 10216 is a potent and selective aldehyde dehydrogenase-2 (ALDH2) inhibitor with IC50s of 29 and 1300 nM for ALDH2 and ALDH1, respectively.

Prunetin can inhibit the aldehyde dehydrogenases in liver. It is a flavonoid compound isolated from the herbs of millettia dielsiana.

NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 > 57 μM).

WIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) with IC50 of 0.3 μM.

Daidzin can inhibit mitochondrial aldehyde dehydrogenase2 with IC50 of 80 nM and ALDH-I selectively (Ki=20 nM). Daidzin is purified from the root of Pueraria lobata with effective anti-atherosclerotic activities.

Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram acts as an allosteric inhibitor of MERS-CoV PLpro but as a competitive (or mixed) inhibitor of SARS-CoV PLpro. It also inhibits pyroptosis by blocking gasdermin D pore formation.

3,4-Dihydroxyphenylacetic Acid is a metabolite of dopamine, it can modulate the aldehyde dehydrogenase (ALDH) activity and protects the cells from the acetaldehyde-induced cytotoxicity in vitro.

Taraxerone, a natural product isolated and purified from the herb of Taraxacum mongolicum Hand. Mazz. with allelopathic and antifungal activities, prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration with the concentration dependent manner.