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货号 产品名 纯度
A717763 3',6'-DICHLOROFLUORAN

95%
A1483462 ALE-0540

98%+
A1532341 Thalidomide-5-NH2-CH2-COOH

98%+
A327589 ANA-12

ANA-12 is antagonist of TrkB with Kd of 10 nM.

99%+
A285925 Selitrectinib

LOXO-195 is a TRK kinase inhibitor (TKI) with IC50 values of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.

99%+
A796121 LM22B-10

LM22B-10 is an agonist of TrkB and TrkC neurotrophin receptor. It can improve survival and increase neurite outgrowth in vitro.

99%+
A638163 GNF-5837

GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively).

99%+
A110513 GW 441756

GW 441756 is an inhibitor of tropomyosin-related kinase A (TrkA) with IC50 of 2 nM.

99%+
A537524 LM22A-4

LM22A-4 is a specific agonist oftyrosine kinase receptor B.

98%
A1176610 CH7057288

98%
A158904 N-Acetyl-5-hydroxytryptamine/N-乙酰-5-羟基色胺

98%
A205378 Larotrectinib/拉罗替尼

LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members.

98%
A306917 Repotrectinib

TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively.

99%
A288219 Belizatinib/贝扎替尼(TSR-011)

Belizatinib is a selective ALK inhibitor with IC50 value of 0.7nM, as well as shows potency against TRK A, B, and C with IC50 values<3nM.

99%+
A395008 Danusertib/达鲁舍替

Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It is modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc.

99%+
A206114 Altiratinib

Altiratinib is a c-MET/TIE-2/VEGFR inhibitor which effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.

98%
A119591 Entrectinib/恩曲替尼

Entrectinib is an oral pan-Trk, ROS1, and ALK inhibitor, with IC50 of 1.7/0.1/0.1 nM, 0.2 nM, and 1.6 nM for Trk A/B/C, ROS1, and ALK, respectively.

99%+
A429803 CE-245677

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

97%
A362609 7,8-Dihydroxyflavone/7,8-二羟基黄酮水合物

7,8-Dihydroxyflavone acts as an agonist of TrkB receptor with Kd of 320 nM with neuroprotective effect.

97%
A108716 Larotrectinib sulfate/硫酸拉曲替尼(LOXO-101)

LOXO-101 sulfate blocks the ATP binding site of the TRK family of receptors with IC50 of 2 nM to 20 nM against TRKA, TRKB, and TRKC.

98%
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