Zinc is known to modulate antiviral and antibacterial immunity and regulate inflammatory response. Certain indications suggest that modulation of zinc status may be beneficial in COVID‑19.
Zinc gluconate may be a PPAR-α (Peroxisome proliferator-activated receptors-α) agonist. Zinc gluconate is efficient in the treatment of several inflammatory dermatoses. In inflammatory LPS-stimulated explants, zinc gluconate significantly upregulated PPAR-α function and mRNA expression level, without changing its epidermal protein expression[1]. Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- α), interleukins-6 1 β, inflammatory8 (IFN ȣ), pancreatic 1L1-β along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8)[2]. Zinc gluconate intervention in patients with ulcerative colitis improves the nutritional status of this mineral in these patients and positively influences their clinical outcome, reinforcing the role of zinc as an important dietary component in disease control[3]. Zinc absorption in humans could be improved by zinc complexation with gluconate[4].
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