Zinc Gluconate
产品说明书
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同义名 : | 葡萄糖酸锌 水合物 ;Zinc gluconate hydrate |
| CAS号 : | 4468-02-4 | |
| 货号 : | A536852 | |
| 分子式 : | C12H22O14Zn | |
| 纯度 : | 98% | |
| 分子量 : | 455.7 | |
| MDL号 : | MFCD00868110 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 50 mg/mL(109.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(109.72 mM)，配合低频超声助溶 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Zinc gluconate may be a PPAR-α (Peroxisome proliferator-activated receptors-α) agonist. Zinc gluconate is efficient in the treatment of several inflammatory dermatoses. In inflammatory LPS-stimulated explants, zinc gluconate significantly upregulated PPAR-α function and mRNA expression level, without changing its epidermal protein expression[1]. Treatment with sage oil (0.042mg/kg IP) and Zinc gluconate orally (150mg/kg) body weight daily for 8 weeks significantly reduced serum glucose, C-reactive protein (CRP), Tumor necrosis factor alpha (TNF- α), interleukins-6 1 β, inflammatory8 (IFN ȣ), pancreatic 1L1-β along with an increase in serum Zinc and pancreatic Zinc transporter 8 (ZNT8)[2]. Zinc gluconate intervention in patients with ulcerative colitis improves the nutritional status of this mineral in these patients and positively influences their clinical outcome, reinforcing the role of zinc as an important dietary component in disease control[3]. Zinc absorption in humans could be improved by zinc complexation with gluconate[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.19mL 0.44mL 0.22mL |
10.97mL 2.19mL 1.10mL |
21.94mL 4.39mL 2.19mL |
| 参考文献 |
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