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cis-4-Hydroxy-L-proline/羟脯氨酸
cis-4-Hydroxy-L-proline/羟脯氨酸
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货号：A209063
同义名：
顺式-4-羟基-L-脯氨酸
/ cis-4-Hydroxy-L-proline
H-cis-Hyp-OH是脯氨酸的一种羟基化衍生物，通常用于合成胶原蛋白，促进胶原蛋白稳定和形成中起关键作用。
cis-4-Hydroxy-L-proline/羟脯氨酸 化学结构
cis-4-Hydroxy-L-proline/羟脯氨酸 3D分子结构
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cis-4-Hydroxy-L-proline/羟脯氨酸 纯度/质量文件 产品仅供科研
货号：A209063
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cis-4-Hydroxy-L-proline/羟脯氨酸 质控信息
cis-4-Hydroxy-L-proline/羟脯氨酸 生物活性
描述
cis-4-Hydroxy-L-proline, an analogue of proline, acts as a collagen production inhibitor. It is capable of inhibiting fibroblast growth by blocking the deposition of triple-helical collagen on the cellular layer. Additionally, it has been shown to suppress the growth of primary N-nitrosomethylurea-induced mammary tumors in rats[1] [2] [3] [4]
cis-4-Hydroxy-L-proline/羟脯氨酸 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
Pulmonary oxygen toxicity model
Subcutaneous injection
200 mg/kg
Twice daily for 14 days
To test whether cis-4-hydroxy-L-proline could prevent collagen accumulation and alveolar enlargement. Results showed that cis-hydroxyproline prevented the accumulation of collagen in the lungs and provided apparent protection from airspace dilatation and decreased lung elasticity.
J Clin Invest. 1980 Mar;65(3):643-51
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cis-4-Hydroxy-L-proline/羟脯氨酸 动物研究
Animal study
肾结石[5]
动物：SD大鼠，雄性，6-8 周龄。
给药：5% HLP，喂食，连续4周。
cis-4-Hydroxy-L-proline/羟脯氨酸 参考文献
[1] Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62.
[2] Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4.
[3] Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7.
[4] Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.
[5] Kumar P, Yang Z, Lever JM, Chávez MD, Fatima H, Crossman DK, Maynard CL, George JF, Mitchell T. Hydroxyproline stimulates inflammation and reprograms macrophage signaling in a rat kidney stone model. Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166442.
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cis-4-Hydroxy-L-proline/羟脯氨酸 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
7.63mL
1.53mL
0.76mL
38.13mL
7.63mL
3.81mL
76.26mL
15.25mL
7.63mL
cis-4-Hydroxy-L-proline/羟脯氨酸 技术信息
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