cis-4-Hydroxy-L-proline

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Chemical Structure| 618-27-9 同义名 : 顺式-4-羟基-L-脯氨酸 ;cis-4-Hydroxy-L-proline
CAS号 : 618-27-9
货号 : A209063
分子式 : C5H9NO3
纯度 : 98%
分子量 : 131.13
MDL号 : MFCD00064319
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(762.6 mM)，配合低频超声助溶
生物活性
描述 cis-4-Hydroxy-L-proline, an analogue of proline, acts as a collagen production inhibitor. It is capable of inhibiting fibroblast growth by blocking the deposition of triple-helical collagen on the cellular layer. Additionally, it has been shown to suppress the growth of primary N-nitrosomethylurea-induced mammary tumors in rats[1].[2].[3].[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.63mL

1.53mL

0.76mL

38.13mL

7.63mL

3.81mL

76.26mL

15.25mL

7.63mL
参考文献

[1]Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62.

[2]Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4.

[3]Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7.

[4]Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.

[5]Kumar P, Yang Z, Lever JM, Chávez MD, Fatima H, Crossman DK, Maynard CL, George JF, Mitchell T. Hydroxyproline stimulates inflammation and reprograms macrophage signaling in a rat kidney stone model. Biochim Biophys Acta Mol Basis Dis. 2022 Sep 1;1868(9):166442.