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Berberine/小檗碱 {[allProObj[0].p_purity_real_show]}

货号:A610272 同义名: 黄连素 / Natural Yellow 18; Umbellatine

Berberine (Natural Yellow 18) 是从中药黄连中分离出的生物碱,以其抗生素特性闻名。它诱导活性氧 (ROS) 生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。硫酸盐形式提高了其生物利用度。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Berberine/小檗碱 化学结构 CAS号:2086-83-1
Berberine/小檗碱 化学结构
CAS号:2086-83-1
Berberine/小檗碱 3D分子结构
CAS号:2086-83-1
Berberine/小檗碱 化学结构 CAS号:2086-83-1
Berberine/小檗碱 3D分子结构 CAS号:2086-83-1
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Berberine/小檗碱 纯度/质量文件 产品仅供科研

货号:A610272 标准纯度: {[allProObj[0].p_purity_real_show]}
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Berberine/小檗碱 生物活性

描述 Berberine is a classical natural medicine, has multiple therapeutic effects for metabolic disorders, microbial infection, neoplasms and inflammation. in vitro, the IC50 of berberine was 80 μM, 100 μM, 200 μM and 300 μM in HCT-116, HepG2, DLD1 and HL-7702, respectively[3]. in vivo, 100 mg/kg/day berberine treatment significantly inhibited the augmented contractile function of middle cerebral artery in diabetic rats[4]. Moreover, Berberine significantly attenuated functional deficits and brain damage associated with TBI up to day 28 post-injury[5].

Berberine/小檗碱 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03097965 Obesity Not Applicable Completed - -
NCT03728244 Graft Pain Gi... 展开 >>ngival Recession 收起 << Phase 1 Phase 2 Not yet recruiting August 2020 -
NCT02737943 Burns Phase 1 Recruiting January 2018 Egypt ... 展开 >> Zagazig University Hospitals Recruiting Zagazig, Alsharkia, Egypt, 44519 Contact: Mohammad S Alsabbahi, As. Lecturer    +201092007426    doctor.sabbahi@gmail.com    Principal Investigator: Mohammad S Alsabbahi, As. Lecturer          Sub-Investigator: Mohamed HA Elsayed, As. Lecturer          Sub-Investigator: Mohamed AM Ebrahim, As. Lecturer          Sub-Investigator: Sameh M Hassan, Intern          Sub-Investigator: Mohamed H Abdelhady, Student          Sub-Investigator: Mohamed A Salama, Student 收起 <<

Berberine/小檗碱 参考文献

[1]Liu L, Liu J, et al. Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats. Biochem Biophys Res Commun. 2015 Mar 20;458(4):796-801.

[2]Zhang XZ, Wang L, et al. Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803. J Med Food. 2014 Sep;17(9):955-62.

[3]La X, Zhang L, Li Z, Yang P, Wang Y. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 2017;8(13):20909-20924.

[4]Ma YG, Zhang YB, Bai YG, et al. Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²⁺ handling in smooth muscle cells. Cardiovasc Diabetol. 2016;15:63. Published 2016 Apr 12.

[5]Chen CC, Hung TH, Lee CY, et al. Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury. PLoS One. 2014;9(12):e115694. Published 2014 Dec 29.

Berberine/小檗碱 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.87mL

2.97mL

1.49mL

29.73mL

5.95mL

2.97mL

Berberine/小檗碱 技术信息

CAS号2086-83-1
分子式C20H18NO4
分子量 336.36
SMILES Code COC1=C(OC)C=CC2=C1C=[N+](CC3)C(C4=C3C=C5C(OCO5)=C4)=C2
MDL No. MFCD01175817
别名 黄连素 ;Natural Yellow 18; Umbellatine
运输蓝冰
InChI Key YBHILYKTIRIUTE-UHFFFAOYSA-N
Pubchem ID 2353
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere, room temperature

溶解方案

DMSO: 17 mg/mL ( (50.54 mM) ,配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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