Berberine

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Chemical Structure| 2086-83-1 同义名 : 黄连素 ;Natural Yellow 18; Umbellatine
CAS号 : 2086-83-1
货号 : A610272
分子式 : C20H18NO4
纯度 : 99%
分子量 : 336.36
MDL号 : MFCD01175817
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 17 mg/mL ( (50.54 mM) ，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Berberine is a classical natural medicine, has multiple therapeutic effects for metabolic disorders, microbial infection, neoplasms and inflammation. in vitro, the IC50 of berberine was 80 μM, 100 μM, 200 μM and 300 μM in HCT-116, HepG2, DLD1 and HL-7702, respectively[3]. in vivo, 100 mg/kg/day berberine treatment significantly inhibited the augmented contractile function of middle cerebral artery in diabetic rats[4]. Moreover, Berberine significantly attenuated functional deficits and brain damage associated with TBI up to day 28 post-injury[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03097965 Obesity Not Applicable Completed - -
NCT03728244 Graft Pain Gi... 展开 >>ngival Recession 收起 << Phase 1 Phase 2 Not yet recruiting August 2020 -
NCT02737943 Burns Phase 1 Recruiting January 2018 Egypt ... 展开 >> Zagazig University Hospitals Recruiting Zagazig, Alsharkia, Egypt, 44519 Contact: Mohammad S Alsabbahi, As. Lecturer    +201092007426    doctor.sabbahi@gmail.com    Principal Investigator: Mohammad S Alsabbahi, As. Lecturer          Sub-Investigator: Mohamed HA Elsayed, As. Lecturer          Sub-Investigator: Mohamed AM Ebrahim, As. Lecturer          Sub-Investigator: Sameh M Hassan, Intern          Sub-Investigator: Mohamed H Abdelhady, Student          Sub-Investigator: Mohamed A Salama, Student 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.97mL

0.59mL

0.30mL

14.87mL

2.97mL

1.49mL

29.73mL

5.95mL

2.97mL
参考文献

[1]Liu L, Liu J, et al. Berberine improves endothelial function by inhibiting endoplasmic reticulum stress in the carotid arteries of spontaneously hypertensive rats. Biochem Biophys Res Commun. 2015 Mar 20;458(4):796-801.

[2]Zhang XZ, Wang L, et al. Synergistic inhibitory effect of berberine and d-limonene on human gastric carcinoma cell line MGC803. J Med Food. 2014 Sep;17(9):955-62.

[3]La X, Zhang L, Li Z, Yang P, Wang Y. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 2017;8(13):20909-20924.

[4]Ma YG, Zhang YB, Bai YG, et al. Berberine alleviates the cerebrovascular contractility in streptozotocin-induced diabetic rats through modulation of intracellular Ca²⁺ handling in smooth muscle cells. Cardiovasc Diabetol. 2016;15:63. Published 2016 Apr 12.

[5]Chen CC, Hung TH, Lee CY, et al. Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury. PLoS One. 2014;9(12):e115694. Published 2014 Dec 29.