Cornin, a natural product isolated and purified from the fruits of Cornus officinalis Sieb. et Zucc.,induces angiogenesis in vitro via a programmed PI3K/Akt/eNOS/VEGF signaling axis and has protective potential against cerebral ischemia injury and its protective effects may be due to amelioration of cerebral mitochondrial function and its antioxidant property.
Verbenalin/马鞭草苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Human neuroblastoma SH-SY5Y cells
20 µM
24 hours
To evaluate the neuroprotective effect of verbenalin against amyloid beta-induced neurotoxicity. Results showed that verbenalin pretreatment significantly reduced Aβ-induced cell death.
Aging (Albany NY). 2020 Mar 29;12(6):5516-5538
Primary human NK cells
10 µM and 30 µM
3 days
Verbenalin significantly enhanced NK killing efficiency in vitro, as determined by real-time killing assays based on plate-reader or high-content live-cell imaging in 3D using primary human NK cells.
Int J Mol Sci. 2023 Apr 12;24(8):7144
Human amnion epithelial cells (hAECs)
20 µM
7 days
Microarray gene expression profiling was conducted to explore the therapeutic potential of verbenalin for AD. Results showed that verbenalin treatment significantly enriched AD-associated gene sets.
Aging (Albany NY). 2020 Mar 29;12(6):5516-5538
Verbenalin/马鞭草苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
B6;C3-Tg(APPswe, PSEN1dE9)85Dbo/Mmjax mice
Alzheimer’s disease animal model
Oral gavage
100 mg/kg and 200 mg/kg
Once daily for 35 days
To evaluate the effect of Verbenalin on Aβ and tau expression in AD animal models. Results showed that Verbenalin reduced Aβ and tau expression in the hippocampus and restored BDNF levels.
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