Investigate the effect of UC2288 on p21 mRNA and protein levels. Results showed an increase in p21 mRNA levels at 4 hours but no change in the fraction of p21 or p-p21 positive cells.
Front Oncol. 2022 Sep 6;12:906194
Kelly cells
10 µM
2 hours, 4 hours and 6 hours
Investigate the effect of UC2288 on p21 mRNA and protein levels. Results showed a decrease in p21 mRNA levels after 2 hours followed by an increase at 4 and 6 hours. Western blot showed reduced p-p21 expression at all time points.
Front Oncol. 2022 Sep 6;12:906194
BCBL1 cells
5 µM
24 and 48 hours
To evaluate the effect of UC2288 on PEL cell survival, results showed that UC2288 alone induced cytotoxic effects and further reduced cell survival when combined with Lovastatin.
IUBMB Life. 2021 Jul;73(7):968-977
BC3 cells
5 µM
24 and 48 hours
To evaluate the effect of UC2288 on PEL cell survival, results showed that UC2288 alone induced cytotoxic effects and further reduced cell survival when combined with Lovastatin.
IUBMB Life. 2021 Jul;73(7):968-977
MIN6 cells
2.5 µM
24 hours
To investigate the effect of UC2288 on apoptosis in MIN6 cells under DNA damage conditions. Results showed that UC2288 inhibited p21 function and significantly increased the frequency of apoptosis in MIN6 cells under DNA damage conditions.
Sci Rep. 2019 Dec 18;9(1):19341
BE(2)-C cells
10 µM
24 hours
Investigate the effect of UC2288 on p21 and p-p21 expression. Western blot showed increased p21 expression and decreased p-p21 expression.
Front Oncol. 2022 Sep 6;12:906194
Normal kidney proximal tubule epithelial cell line HK2
10 µM
24 hours
UC2288 markedly decreased p21 protein levels.
Cancer Biol Ther. 2013 Mar;14(3):278-85
Ovarian cancer cell line Hey
10 µM
24 hours
UC2288 markedly decreased p21 protein levels.
Cancer Biol Ther. 2013 Mar;14(3):278-85
Renal cell carcinoma cell line ACHN
10 µM
24 hours
UC2288 markedly decreased p21 protein levels.
Cancer Biol Ther. 2013 Mar;14(3):278-85
Renal cell carcinoma cell line Caki-1
10 µM
24 hours
UC2288 markedly decreased p21 protein levels.
Cancer Biol Ther. 2013 Mar;14(3):278-85
Renal cell carcinoma cell line 786-O
10 µM
24 hours
UC2288 decreased p21 protein levels independently of p53 activity, via transcriptional or post-transcriptional regulation.
Cancer Biol Ther. 2013 Mar;14(3):278-85
5-8F
4 µM, 6 µM, 8 µM, 12 µM
24 hours, 48 hours
To evaluate the inhibitory effect of UC2288 on the proliferation of 5-8F cells, the results showed that UC2288 significantly inhibited cell proliferation in a dose- and time-dependent manner, and the effect was better than that of cisplatin.
J Cancer. 2021 Jan 1;12(4):988-995
CNE-2
4 µM, 6 µM, 8 µM, 12 µM
24 hours, 48 hours
To evaluate the inhibitory effect of UC2288 on the proliferation of CNE-2 cells, the results showed that UC2288 significantly inhibited cell proliferation in a dose- and time-dependent manner.
J Cancer. 2021 Jan 1;12(4):988-995
Amnion Epithelial Cells (AECs)
20 µM
48 hours
UC2288, as a p21 inhibitor, was used to block Dex-induced senescence in amnion epithelial cells. Results showed that UC2288 significantly reduced Dex-induced cellular senescence.
To investigate the effect of UC2288 on apoptosis in β-cells of db/db mice under DNA damage conditions. Results showed that UC2288 inhibited p21 function and significantly increased the frequency of apoptosis in β-cells under DNA damage conditions.
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