Theaflavin (TF) is a suitable natural inhibitor against influenza A (H1N1) neuraminidase. Theaflavin, found in green tea, is observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Theaflavin is a plant product traditionally used for treatment of influenza infection. Theaflavin derivatives have shown pronounced antiviral activity[3]. Theaflavin was strong inhibitors of OATP (Organic anion-transporting polypeptide) 2B1-mediated E3S uptake. Theaflavin showed a significantly higher uptake into the OATP2B1-expressing HEK293 cells than the control cells. The concentration dependence of the uptake of theaflavin was determined over a range of concentrations (0.5-100 μM) and the kinetic parameters (Km and Vmax) of theaflavin uptake were found to be 5.12 ± 0.67 μM and 41.6 ± 1.3 pmol/mg protein/min, respectively[4]. TF improved survival of irradiated wild-type mice and ameliorated TBI-induced (total body irradiation) hematopoietic injury by attenuating myelosuppression and myeloid skewing, increasing HSC (hematopoietic stem cell) frequency, and promoting reconstitution of irradiated HSCs. Furthermore, TF inhibited TBI-induced HSC senescence[5].
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