Theaflavin

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Chemical Structure| 4670-05-7 同义名 : -
CAS号 : 4670-05-7
货号 : A218957
分子式 : C29H24O12
纯度 : 99%+
分子量 : 564.49
MDL号 : MFCD03427500
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(88.57 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(3.54 mM)
生物活性
描述 Theaflavin (TF) is a suitable natural inhibitor against influenza A (H1N1) neuraminidase. Theaflavin, found in green tea, is observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Theaflavin is a plant product traditionally used for treatment of influenza infection. Theaflavin derivatives have shown pronounced antiviral activity[3]. Theaflavin was strong inhibitors of OATP (Organic anion-transporting polypeptide) 2B1-mediated E3S uptake. Theaflavin showed a significantly higher uptake into the OATP2B1-expressing HEK293 cells than the control cells. The concentration dependence of the uptake of theaflavin was determined over a range of concentrations (0.5-100 μM) and the kinetic parameters (Km and Vmax) of theaflavin uptake were found to be 5.12 ± 0.67 μM and 41.6 ± 1.3 pmol/mg protein/min, respectively[4]. TF improved survival of irradiated wild-type mice and ameliorated TBI-induced (total body irradiation) hematopoietic injury by attenuating myelosuppression and myeloid skewing, increasing HSC (hematopoietic stem cell) frequency, and promoting reconstitution of irradiated HSCs. Furthermore, TF inhibited TBI-induced HSC senescence[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03194620 Healthy Not Applicable Completed - United States, California ... 展开 >> UC Davis Davis, California, United States, 95616 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.86mL

1.77mL

0.89mL

17.72mL

3.54mL

1.77mL
参考文献

[1]Sahoo M, Jena L, et al. Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking. Genomics Inform. 2016 Sep;14(3):96-103.

[2]Fatima M, Kesharwani RK, et al. Protective effect of theaflavin on erythrocytes subjected to in vitro oxidative stress. Biochem Res Int. 2013;2013:649759.

[3]Sahoo M, Jena L, Rath SN, Kumar S. Identification of Suitable Natural Inhibitor against Influenza A (H1N1) Neuraminidase Protein by Molecular Docking. Genomics Inform. 2016;14(3):96-103

[4]Kondo A, Narumi K, Ogura J, et al. Organic anion-transporting polypeptide (OATP) 2B1 contributes to the cellular uptake of theaflavin. Drug Metab Pharmacokinet. 2017;32(2):145-150

[5]Han X, Zhang J, Xue X, et al. Theaflavin ameliorates ionizing radiation-induced hematopoietic injury via the NRF2 pathway. Free Radic Biol Med. 2017;113:59-70