Tamarixetin, a natural product isolated and purified from the herbs of Heracleum stenopterum with potential protective effect against cancer and cardiovascular diseases, can inhibit proliferation in a concentration- and time-dependent manner, induce apoptosis and block cell cycle progression at G2 -M phase.
Tamarixetin/柽柳黄素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MCF-7
50 µM
48 hours
Inhibition of cell proliferation, inhibition rate of 92.70%
Sci Rep. 2022 Mar 10;12(1):3966
NRK-52E cells
12.5 µM
24 hours
Tamarixetin did not show significant cytoprotective effects in NRK-52E cells.
Molecules. 2022 Feb 15;27(4):1319
HK-2 cells
12.5 µM
24 hours
Tamarixetin showed a cytoprotective trend in HK-2 cells, but the results were not significant.
Molecules. 2022 Feb 15;27(4):1319
T47D
100 µM
48 hours
Inhibition of cell proliferation, inhibition rate of 86.68%
Sci Rep. 2022 Mar 10;12(1):3966
MDA-MB-453
50 µM
48 hours
Inhibition of cell proliferation, inhibition rate of 44.97%
Sci Rep. 2022 Mar 10;12(1):3966
MDA-MB-468
50 µM
48 hours
Inhibition of cell proliferation, inhibition rate of 88.14%
Sci Rep. 2022 Mar 10;12(1):3966
MDA-MB-231
50 µM
48 hours
Inhibition of cell proliferation, inhibition rate of 71.02%
Sci Rep. 2022 Mar 10;12(1):3966
Primary breast cancer cells
50 µM
48 hours
Inhibition of cell proliferation, inhibition rate of 87.20%
Sci Rep. 2022 Mar 10;12(1):3966
Chondrocytes differentiated from human bone-marrow-derived mesenchymal stem cells (hBMMSCs)
2, 5, 10, 20 µM
48 hours
To evaluate the effects of Tamarixetin on chondrocyte viability and chondrogenic properties. Results showed that Tamarixetin did not induce observable cytotoxicity and significantly increased glycosaminoglycan (GAG) content and the expression of chondrogenic markers (COL2, ACAN, and SOX9).
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