There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
To investigate the inhibitory effect of TPCK on PMA-induced respiratory burst in neutrophils. Results showed that TPCK pretreatment prevents PMA-induced p47phox phosphorylation and translocation, thereby inhibiting NADPH oxidase activation.
Biochem J. 2005 Mar 15;386(Pt 3):549-56
BALENLM 17 and A20 B lymphoma cells
15 µM (A20 cells), 25 µM (BALENLM 17 cells)
10-14.5 hours
TPCK treatment induces apoptosis in BALENLM 17 and A20 B lymphoma cells.
EMBO J. 1996 Sep 2;15(17):4682-90
Normal murine splenic B lymphocytes
25 µM
12 hours
TPCK treatment induces apoptosis in normal murine splenic B lymphocytes.
EMBO J. 1996 Sep 2;15(17):4682-90
WEHI231 cells
25 µM
1-5 hours
TPCK treatment inhibits NF-κB/Rel binding activity and induces apoptosis in WEHI231 cells.
EMBO J. 1996 Sep 2;15(17):4682-90
NIH 3T3 fibroblasts
20 µM
3 hours
TPCK blocks degradation of H2a precursor but does not affect ER-to-Golgi transport
J Cell Biol. 1991 Jun;113(5):997-1007
HepG2 cells
20 µM
4 hours
TPCK partially blocks degradation of H2b but does not affect its transport and maturation
J Cell Biol. 1991 Jun;113(5):997-1007
L. infantum promastigotes
11.3 µM (IC50)
72 hours
To evaluate the antileishmanial activity of TPCK against L. infantum promastigotes, results showed significant antiparasitic effects
Pharmaceutics. 2022 Jun 29;14(7):1373
L. amazonensis (Josefa strain) promastigotes
31.7 µM (IC50)
72 hours
To evaluate the antileishmanial activity of TPCK against L. amazonensis promastigotes, results showed significant antiparasitic effects
Pharmaceutics. 2022 Jun 29;14(7):1373
L. amazonensis (PH8 strain) promastigotes
14.6 µM (IC50)
72 hours
To evaluate the antileishmanial activity of TPCK against L. amazonensis promastigotes, results showed significant antiparasitic effects
Pharmaceutics. 2022 Jun 29;14(7):1373
Peritoneal macrophages
138.8 µM (CC50)
72 hours
To evaluate the toxicity of TPCK on mammalian cells, results showed low toxicity of TPCK to mammalian cells
Pharmaceutics. 2022 Jun 29;14(7):1373
TPCK 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
BALB/c mice
L. amazonensis infection model
Intraperitoneal injection
15, 30, 45, 60 mg/kg
Three times a week, totaling 10 doses
To evaluate the therapeutic effect of TPCK on L. amazonensis-infected mice, results showed TPCK significantly reduced lesion size and parasite load
搜索
HazMat Fee +
