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/ Streptozotocin/链脲菌素

Streptozotocin/链脲菌素 {[allProObj[0].p_purity_real_show]}

货号：A667625 同义名： 链脲佐菌素 / NSC-85998; SZN

Streptozotocin (Streptozocin) 是一种广泛用于实验动物中诱导糖尿病的抗生素。Streptozotocin 通过葡萄糖转运蛋白 (GLUT2) 进入 β 细胞并导致 DNA 烷基化，从而引起 β 细胞凋亡。

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Streptozotocin/链脲菌素 化学结构 CAS号：18883-66-4
Streptozotocin/链脲菌素 化学结构
CAS号：18883-66-4
Streptozotocin/链脲菌素 3D分子结构
CAS号：18883-66-4
Streptozotocin/链脲菌素 化学结构 CAS号：18883-66-4
Streptozotocin/链脲菌素 3D分子结构 CAS号：18883-66-4
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Streptozotocin/链脲菌素 纯度/质量文件 产品仅供科研

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Streptozotocin/链脲菌素 生物活性

描述 The alkylation of DNA by carcinogens such as the alkyl nitrosoureas is a critical event in the induction of tumors by these compounds. Streptozotocin, an antibiotic widely used for induction of diabetes in experimental animals and for the treatment of pancreatic neoplasms, was shown to be a potent methylating agent reacting with DNA in vitro to form methylated purines. Rats received streptozotocin (21 mg/kg; 2 mCi/kg) by i.v. injection for 2 hours before death. The liver was alkylated to the greatest extent followed by the kidney. In both of these organs, the degree of methylation was significantly greater than that observed with N-methyl-N-nitrosourea. While methylation of brain DNA by streptozotocin was very low, suggesting that the compound does not penetrate well into the nervous system[3]. Male C57BL/6 mice were under inhalation anesthesia injected via the penile vein with streptozocin (180 mg/kg). Treated mice showed elevated blood glucose levels 48 h after drug injection and reduced body weight significantly compared with control group. Streptozocin also significantly attenuated the numbers of splenocytes and white blood cells (WBC) at 96 h post injection[4].

Streptozotocin/链脲菌素 细胞实验

Cell Line
Concentration Treated Time Description References
LLC-PK1 cells 10 mM 24 hours and 72 hours To evaluate the protective effect of IOEs on STZ-induced renal tubular cell injury, results showed that EtCE-EA increased cell survival at both 24 and 72 hours. Int J Mol Sci. 2023 Feb 23;24(5):4443.

Streptozotocin/链脲菌素 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice 3xTg-AD mice Intracerebroventricular injection 3.0 mg/kg Single injection, lasting 3-6 weeks To investigate the effects of STZ on cognitive function and Alzheimer-like brain abnormalities in 3xTg-AD mice. Results showed that STZ exacerbated impairment of short-term and spatial reference memory, increased tau hyperphosphorylation and neuroinflammation, disturbed brain insulin signaling, and decreased synaptic plasticity and amyloid β peptides in the brain. Mol Neurobiol. 2014 Feb;49(1):547-62
Rats Streptozotocin-induced type 1 diabetes model Intraperitoneal injection 50 mg/kg Single injection The study aimed to investigate the therapeutic effects of hDPSCs transplantation on parotid gland injury in a rat model of STZ-induced type 1 diabetes. Results showed that hDPSCs transplantation decreased blood glucose, improved parotid gland weight and salivary flow rate, reduced oxidative stress, and promoted parotid cell regeneration. Stem Cell Res Ther. 2021 Nov 14;12(1):577
Sprague-Dawley rats Streptozotocin-induced diabetic rat model Intraperitoneal injection 60 mg/kg Single injection To investigate the effect of glycemic variability on peripheral nerve damage in streptozotocin-induced diabetic rats. The results suggest that glucose control itself is more important than glucose fluctuation in preventing peripheral nerve damage. Diabetes Metab J. 2022 Jan;46(1):117-128
Mice 1/3 NT + STZ-induced diabetic nephropathy model Intraperitoneal injection 75 mg/kg and 100 mg/kg Once a week for 7 days To evaluate the protective effect of EtCE-EA on diabetic nephropathy, results showed that EtCE-EA effectively improved renal function indicators and reduced renal damage. Int J Mol Sci. 2023 Feb 23;24(5):4443.
C57BL/6J mice Streptozotocin-induced diabetes model Intraperitoneal injection Single high dose 150 mg/kg or multiple low doses 50 mg/kg Single high dose administered once, multiple low doses administered over 5 consecutive days To study the effects of streptozotocin on pancreatic β-cells and observe the progression of hyperglycemia and diabetes Sci Data. 2022 Sep 10;9(1):558
Mice Diet-induced obesity and low-dose streptozotocin-induced hyperglycemia model Intraperitoneal injection 50 mg/kg Five consecutive days To evaluate the effect of GPR39 deletion on post-ischemic revascularization in hyperglycemic mice. Results showed that GPR39 deletion significantly accelerated blood perfusion recovery and reduced tissue necrosis in hyperglycemic mice. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2208541120
Mice Model of maternal diabetes-induced NTDs Intravenous injection in the tail vein 75 mg/kg For 2 consecutive days To study the effect of PKCα on neural tube defects under diabetic pregnancy conditions, results showed PKCα activation leads to autophagy impairment and neural tube defects Nat Commun. 2017 May 5;8:15182
Mice Type-1 diabetic mouse model Intraperitoneal injection 50 mg/kg body weight Six consecutive injections, maintained for 32 weeks To study the effect of L-Anserine nitrate on kidney fibrosis in a type-1 diabetic mouse model. Results showed that Cndp1-KO mice had significantly increased kidney anserine and carnosine concentrations, reduced glycative and oxidative stress in the kidney, and mitigated interstitial inflammation and fibrosis. Antioxidants (Basel). 2023 Jun 14;12(6):1270

Streptozotocin/链脲菌素 动物研究

Animal study 糖尿病[5]
动物：C57BL/6 小鼠，雌雄皆可，10周龄。
给药：200 mg/kg ，腹腔注射 ，单次高剂量

Streptozotocin/链脲菌素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01362530 Chemotherapy Induced Nausea an... 展开 >>d Vomiting 收起 << Phase 3 Completed - -
NCT01362530 - Completed - -
NCT00003543 Colorectal Cancer Phase 1 Completed - United States, New York ... 展开 >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 收起 <<

Streptozotocin/链脲菌素 参考文献

[1]Diab RA, Fares M, et al. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8.

[2]Bennett RA, Pegg AE. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90.

[3]Bennett RA, Pegg AE. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 1981 Jul;41(7):2786-90. PMID: 6454479.

[4]Diab RA, Fares M, Abedi-Valugerdi M, Kumagai-Braesch M, Holgersson J, Hassan M. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies. Immunol Lett. 2015 Feb;163(2):193-8. doi: 10.1016/j.imlet.2014.12.006. Epub 2015 Jan 5. PMID: 25573197.

[5]Marino F, Salerno N, Scalise M, Salerno L, Torella A, Molinaro C, Chiefalo A, Filardo A, Siracusa C, Panuccio G, Ferravante C, Giurato G, Rizzo F, Torella M, Donniacuo M, De Angelis A, Viglietto G, Urbanek K, Weisz A, Torella D, Cianflone E. Streptozotocin-Induced Type 1 and 2 Diabetes Mellitus Mouse Models Show Different Functional, Cellular and Molecular Patterns of Diabetic Cardiomyopathy. Int J Mol Sci. 2023 Jan 6;24(2):1132.

Streptozotocin/链脲菌素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.77mL

0.75mL

0.38mL

18.85mL

3.77mL

1.89mL

37.70mL

7.54mL

3.77mL

Streptozotocin/链脲菌素 技术信息

CAS号18883-66-4
分子式C8H15N3O7
分子量 265.22
SMILES Code O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](NC(N(C)N=O)=O)[C@H]1O
MDL No. MFCD00006607
别名 链脲佐菌素 ;NSC-85998; SZN; SZC; NRRL 2697; AI3-50821; NCI-C03167; NSC 37917; Estreptozocin; STZ; U 9889
运输蓝冰
InChI Key ZSJLQEPLLKMAKR-GKHCUFPYSA-N
Pubchem ID 29327
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C
溶解方案

DMSO: 250 mg/mL(942.61 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 110 mg/mL(414.75 mM)

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: Streptozotocin | Streptozocin;NSC-85998;streptozotocin. SZN;SZC;NRRL 2697;AI3-50821;NCI-C03167;NSC 37917;Estreptozocin;STZ;U 9889 | 链脲佐菌素 | Diabete Model | DNA Alkylator/Crosslinker | AmBeed-信号通路专用抑制剂 | Streptozotocin/链脲菌素 纯度/质量文件 | Streptozotocin/链脲菌素 生物活性 | Streptozotocin/链脲菌素 临床数据 | Streptozotocin/链脲菌素 参考文献 | Streptozotocin/链脲菌素 实验方案 | Streptozotocin/链脲菌素 技术信息

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