Spermine是一种自由基清除剂，能够保护 DNA 免受自由基的氧化损伤，具有抗病毒作用，广泛用于营养补充和治疗饮食不足或失衡。
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine at physiologically relevant concentrations inhibits ROS-induced DNA damage, with maximal inhibition observed at 1 to 2 mM. These concentrations are well within the estimates for the physiological concentrations of spermine[1]. Spermine can promote the antioxidant capacity by increasing enzymatic antioxidant capacity, glutathione content and clearance of oxygen radicals; spermine significantly increased the mRNA levels of enzymatic antioxidant substances, NF-E2-related nuclear factor 2, Kelch-like ECH-associated protein 1, and the mammalian target of rapamycin but decreased the mRNA levels of ribosomal p70 S6 kinase in the liver and longissimus dorsi of the piglets[2]. Decreased spermine level may be used as an indicator of malignant phenotype transformation from normal to malignant tissue in prostate. The mechanism between spermine and PCa (prostate cancer) development are possibly related to the regulation of polyamine metabolism, cancer-driving pathways, oxidative stress, anticancer immunosurveillance, and apoptosis regulation[3]. Moreover, spermine facilitates selective autophagic degradation of prion aggregates by binding to microtubule protein Tubb6[4].
United States, Florida
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University of Florida
Gainesville, Florida, United States, 32611
United States, New York
Columbia University Medical Center
New York, New York, United States, 10032
United States, Washington
University of Washington
Seattle, Washington, United States, 96104 收起 <<
United States, Florida
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University of Florida
Gainesville, Florida, United States, 32611
United States, New York
Columbia University Medical Center
New York, New York, United States, 10032
United States, Washington
University of Washington
Seattle, Washington, United States, 96104 收起 <<
United States, Maryland
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, United States, 21287
Puerto Rico
University of Puerto Rico
San Juan, Puerto Rico, 00936 收起 <<
United States, New York
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Montefiore Medical Center
Recruiting
Bronx, New York, United States, 10467
Contact: Alyssa Asaro, BA 718-920-5636 aasaro@montefiore.org 收起 <<
Cancer
Solid ... 展开 >>Tumor
Solid Carcinoma
Advanced Cancer 收起 <<
Phase 1
Recruiting
October 2020
United States, Texas
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Mays Cancer Center at UT Health San Antonio
Not yet recruiting
San Antonio, Texas, United States, 78229
Contact: Rachel Ortiz-Wong 210-450-5055 wongro@uthscsa.edu
Principal Investigator: John Sarantopoulos, MD
Next Oncology
Recruiting
San Antonio, Texas, United States, 78240
Contact: Research Coordinator 210-595-5300 crosas@nextsat.com
Principal Investigator: Anthony Tolcher, MD 收起 <<
France
... 展开 >> CLCC-Institut Bergonie, service d'anesthésie réanimation, 229 cours de l'Argonne
Bordeaux, France, 33000
département d'anesthésie-réanimation 3, hôpital Pellegrin
Bordeaux, France, 33076
CLCC Alexis Vautrin
Nancy, France, 54511
APHParis Hôpital Pitié Salpétrière - Dépt. d'anesthésie réanimation
Paris, France, 75013
CLCC Réné Huguenin de Saint Cloud
Saint Cloud, France, 92210 收起 <<
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