Spermine
产品说明书
 |
同义名 : | NSC 268508; Neuridine; 1,5,10,14-Tetraazatetradecane; Musculamine; Gerontine |
| CAS号 : | 71-44-3 | |
| 货号 : | A109610 | |
| 分子式 : | C10H26N4 | |
| 纯度 : | 90% | |
| 分子量 : | 202.34 | |
| MDL号 : | MFCD00008215 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 120 mg/mL(593.06 mM)，配合低频超声助溶 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine at physiologically relevant concentrations inhibits ROS-induced DNA damage, with maximal inhibition observed at 1 to 2 mM. These concentrations are well within the estimates for the physiological concentrations of spermine[1]. Spermine can promote the antioxidant capacity by increasing enzymatic antioxidant capacity, glutathione content and clearance of oxygen radicals; spermine significantly increased the mRNA levels of enzymatic antioxidant substances, NF-E2-related nuclear factor 2, Kelch-like ECH-associated protein 1, and the mammalian target of rapamycin but decreased the mRNA levels of ribosomal p70 S6 kinase in the liver and longissimus dorsi of the piglets[2]. Decreased spermine level may be used as an indicator of malignant phenotype transformation from normal to malignant tissue in prostate. The mechanism between spermine and PCa (prostate cancer) development are possibly related to the regulation of polyamine metabolism, cancer-driving pathways, oxidative stress, anticancer immunosurveillance, and apoptosis regulation[3]. Moreover, spermine facilitates selective autophagic degradation of prion aggregates by binding to microtubule protein Tubb6[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02915757 | Depression Diagnosis | Not Applicable | Unknown | March 2017 | France ... 展开 >> Montpellier University Hospital Montpellier, France, 34295 收起 << |
| NCT02855918 | Major Depression | Not Applicable | Not yet recruiting | July 2019 | France ... 展开 >> University Hospital Not yet recruiting Montpêllier, France, 34295 Contact: Catherine GENTY, MD +33 4 67 99 61 45 75 c-genty@chu-montpellier.fr Contact: Aurélie CAZALS, MD +33 4 67 33 63 76 a-cazals@chu-montpelier.fr 收起 << |
| NCT01095731 | Aneurysmal Subarachnoid Hemorr... 展开 >>hage 收起 << | Phase 2 | Completed | - | United States, Florida ... 展开 >> University of Florida Gainesville, Florida, United States, 32611 United States, New York Columbia University Medical Center New York, New York, United States, 10032 United States, Washington University of Washington Seattle, Washington, United States, 96104 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.94mL 0.99mL 0.49mL |
24.71mL 4.94mL 2.47mL |
49.42mL 9.88mL 4.94mL |
| 参考文献 |
|---|