There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
To investigate the distribution and antioxidant activity of sinapine in cardiomyocytes. Results showed that sinapine could enter cardiomyocytes and accumulate in both cytosol and mitochondria, while sinapic acid was only present in the cytosol.
Redox Biol. 2020 Jul;34:101554
HepG2 cells
0.4 mM
24 hours
To investigate the inhibitory effect of Sinapine on lipid accumulation in HepG2 cells. Results showed that 0.4 mM Sinapine inhibited 27.5% of lipid accumulation, downregulated SREBP-1c and FAS gene expression, and upregulated PPAR-α and ACOX2 gene expression.
RSC Adv. 2020 Jun 3;10(36):21248-21258
Sinapine/芥子碱 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Male Wistar rats
Cardiac ischemia-reperfusion injury model
Oral
200 mg/kg
Single dose, observed for 120 minutes
To evaluate the bioavailability of sinapine in vivo and its cardioprotective effects. Results demonstrated that sinapine could be detected in plasma and cardiac tissues after oral administration, significantly reducing ROS production during cardiac ischemia-reperfusion and improving functional recovery.
Redox Biol. 2020 Jul;34:101554
C57BL/6J mice
High-fat diet-induced obesity and fatty liver model
Dietary supplementation
500 mg/kg oil
12 weeks
To investigate the preventive effect of Sinapine on high-fat diet-induced obesity and fatty liver. Results showed that Sinapine significantly reduced body weight gain, fat accumulation, and fatty liver formation, decreased TG, LDL-C, ALT, and AST levels, and regulated lipid metabolism by downregulating SREBP-1c and FAS gene expression and upregulating PPAR-α and ACOX1 gene expression.
RSC Adv. 2020 Jun 3;10(36):21248-21258
Sinapine/芥子碱 实验方案
计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.22mL
0.64mL
0.32mL
16.11mL
3.22mL
1.61mL
32.22mL
6.44mL
3.22mL
Sinapine/芥子碱 技术信息
CAS号
18696-26-9
分子式
C16H24NO5
分子量
310.37
SMILES Code
O=C(OCC[N+](C)(C)C)/C=C/C1=CC(OC)=C(O)C(OC)=C1
MDL No.
N/A
别名
运输
蓝冰
InChI Key
HUJXHFRXWWGYQH-UHFFFAOYSA-O
Pubchem ID
5280385
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formKeep in dark place, inert atmosphere, 2-8°C
搜索
HazMat Fee +
