There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Thromboxane synthase (TXAS) is a P450 epoxygenase that synthesizes thromboxane A2 (TXA2), a potent mediator of platelet aggregation, vasoconstriction and bronchoconstriction[3]. Seratrodast (AA 2414) is an anti-asthmatic agent and a potent and selective thromboxane A2 receptor (TP) antagonist[4]. Seratrodast inhibited peroxide-induced vasoconstriction in the human placenta, as well as peroxide- induced increases in the placental secretion rates of lipid peroxides and thromboxane, but only partially inhibited peroxide-induced increases in the placental secretion rate of prostacyclin[5]. Seratrodast reduced the overproduction of TxB2 in both bronchoalveolar lavage fluid and lung tissues. Cigarette smoke exposure markedly increased AB/PAS-stained goblet cells and rat Muc5ac expression in the airway, which was significantly attenuated by seratrodast administration. The induced phosphorylation of ERK and p38 was also attenuated by seratrodast[6]. The anti-asthmatic activity of AA-2414 has been studied in vivo and in vitro. Experimental allergic asthma was inhibited by orally administered AA-2414 in a dose-dependent manner. AA-2414, 0.08-1.25 mg/kg (p.o.), inhibited the bronchconstriction in guinea pigs induced by a prostaglandin endoperoxide analogue (U-46619), leukotriene D4 (LTD4), and platelet activating factor (PAF) with a long duration of action. The compound did not inhibit histamine-induced bronchoconstriction. AA-2414 reduced the induction of pulmonary inflation caused by LTD4 aerosol inhalation. AA-2414 competitively inhibited the contractile response to U-46619 in guinea pig tracheal and parenchymal strips and dog saphenous vein strips with pA2 values of 7.69, 8.29 and 6.79, respectively[7].
Seratrodast/塞曲司特 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
Rat mesenteric vascular bed
Perfusion
1 μM
5 minutes
To assess the effect of seratrodast (TXA2 receptor antagonist) on vasodilator responses. Results showed that seratrodast significantly augmented vasodilator responses induced by PNS, CGRP, isoprenaline, and SNP.
Br J Pharmacol. 2008 May;154(1):32-40
Golden hamsters
High-fat diet-induced obesity model
Gavage
2 mL/day
Twice daily for 8 weeks
To study the effect of milk intake on blood lipid health, results showed that milk intake reduced serum TG, TC, and LDL-C levels
Metabolites. 2024 Dec 7;14(12):688
Guinea pigs
Ovalbumin-sensitized guinea pigs
Oral
3 mg/kg
Single administration
Evaluate the inhibitory effect of Seratrodast on U46619-induced bronchoconstriction. Results showed that Seratrodast significantly inhibited U46619-induced bronchoconstriction with a maximum inhibition rate of 94%.
Mucopolysaccharidosis Type 3 A... 展开 >> Sanfilippo Syndrome 收起 <<
Phase 1
Phase 2
Recruiting
December 2020
United States, Ohio
... 展开 >>
Nationwide Children's Hospital
Recruiting
Columbus, Ohio, United States, 43205
Contact: Krista Kunkler 614-722-2238 krista.kunkler@nationwidechildrens.org
Australia, South Australia
Women's and Children's Hospital
Recruiting
North Adelaide, South Australia, Australia, 5006
Contact: Louise Jaensch 08 8161 7295 louise.jaensch@sa.gov.au
Principal Investigator: Nicholas Smith, MD
Spain
Hospital Clínico Universitario de Santiago
Recruiting
Santiago De Compostela, Spain, 15706
Contact: Maria Luz Couce, MD +34 981 950 151 maria.luz.couce.pico@sergas.es
Contact: Maria Jose de Castro, MD +34 981 955 627 maria.jose.de.castro.lopez@sergas.es 收起 <<
Mucopolysaccharidosis Type 3 A... 展开 >> Sanfilippo Syndrome 收起 <<
Phase 1
Phase 2
Recruiting
December 2020
United States, Ohio
... 展开 >>
Nationwide Children's Hospital
Recruiting
Columbus, Ohio, United States, 43205
Contact: Krista Kunkler 614-722-2238 krista.kunkler@nationwidechildrens.org
Australia, South Australia
Women's and Children's Hospital
Recruiting
North Adelaide, South Australia, Australia, 5006
Contact: Louise Jaensch 08 8161 7295 louise.jaensch@sa.gov.au
Principal Investigator: Nicholas Smith, MD
Spain
Hospital Clínico Universitario de Santiago
Recruiting
Santiago De Compostela, Spain, 15706
Contact: Maria Luz Couce, MD +34 981 950 151 maria.luz.couce.pico@sergas.es
Contact: Maria Jose de Castro, MD +34 981 955 627 maria.jose.de.castro.lopez@sergas.es 收起 <<
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