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S-Methoprene/S -(+)-烯虫酯 {[allProObj[0].p_purity_real_show]}

货号:A662508 同义名: (+)-Methoprene; (7S)-Methoprene

S-Methoprene是一种昆虫幼年激素的类似物,作为有效的杀虫剂,能够阻止昆虫从蛹期转变为成虫。此外,S-Methoprene 还是 CB(1) 受体(Cannabinoid Receptor)的配体,能抑制 CB1 受体拮抗剂与 CB1 受体的结合

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
S-Methoprene/S -(+)-烯虫酯 化学结构 CAS号:65733-16-6
S-Methoprene/S -(+)-烯虫酯 化学结构
CAS号:65733-16-6
S-Methoprene/S -(+)-烯虫酯 3D分子结构
CAS号:65733-16-6
S-Methoprene/S -(+)-烯虫酯 化学结构 CAS号:65733-16-6
S-Methoprene/S -(+)-烯虫酯 3D分子结构 CAS号:65733-16-6
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S-Methoprene/S -(+)-烯虫酯 纯度/质量文件 产品仅供科研

货号:A662508 标准纯度: {[allProObj[0].p_purity_real_show]}
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S-Methoprene/S -(+)-烯虫酯 生物活性

描述 S-Methoprene is an insect juvenile hormone analog and an effective insecticide that inhibits the development from pupa to adult stage. It also acts as a ligand for the CB1 receptor, blocking the binding of the CB1 receptor antagonist [3H]CP-55940 with an IC50 of 19.31 μM[1].[2].
体外研究

Phenylmethylsulfonyl fluoride (PMSF) is a chemical that interferes with binding activities in biological assays. S-Methoprene at a concentration of 4 μM inhibits the binding of [3H]CP-55940 to mouse meninges by 27.32± 4.11% and 28.16± 4.17% in the absence and presence of 50 μM PMSF, respectively[2].

S-Methoprene is an inhibitor of CP-55940-stimulated binding of [35S]GTPγS to mouse meninges. It inhibits CB1 receptor binding in a concentration-dependent manner, with a dissociation constant (Ki) of 2.13 μM[2].

S-Methoprene/S -(+)-烯虫酯 参考文献

[1]Adnan SM, et al. Accelerated Sexual Maturation in Methoprene-Treated Sterile and Fertile Male Queensland Fruit Flies (Diptera: Tephritidae), and Mosquito Larvicide as an Economical and Effective Source of Methoprene. J Econ Entomol. 2019 Dec 9;112(6):2842-2849.

[2]Dhopeshwarkar AS, et al. The actions of benzophenanthridine alkaloids, piperonyl butoxide and (S)-methoprene at the G-protein coupled cannabinoid CB₁ receptor in vitro. Eur J Pharmacol. 2011 Mar 1;654(1):26-32.

S-Methoprene/S -(+)-烯虫酯 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.22mL

0.64mL

0.32mL

16.10mL

3.22mL

1.61mL

32.21mL

6.44mL

3.22mL

S-Methoprene/S -(+)-烯虫酯 技术信息

CAS号65733-16-6
分子式C19H34O3
分子量 310.47
SMILES Code COC(C)(C)CCC[C@H](C)C\C=C\C(\C)=C\C(=O)OC(C)C
MDL No. MFCD00867612
别名 (+)-Methoprene; (7S)-Methoprene; Preco; ZR 2458; d-Methoprene; (S)-(+)-Methoprene
运输蓝冰
InChI Key NFGXHKASABOEEW-GYMWBFJFSA-N
Pubchem ID 1711973
存储条件

In solvent -20°C:3-6个月-80°C:12个月

溶解方案

DMSO: 105 mg/mL(338.2 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
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