S-Adenosyl-L-methionine | S-腺苷-L-甲硫氨酸 | S-Adenosyl methionine | Methyl Group Donor

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S-Adenosyl-L-methionine {[allProObj[0].p_purity_real_show]}

货号：A132774 同义名： S-腺苷-L-甲硫氨酸;S-腺苷甲硫氨酸 / S-Adenosyl methionine; AdoMet

Ademetionine is a naturally-occurring substance which is a methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. S-adenosylmethionine could form complex with SARS-CoV-2 nsp10-nsp16 2’-O-methyltransferase.

S-Adenosyl-L-methionine 化学结构
CAS号：29908-03-0

S-Adenosyl-L-methionine 3D分子结构
CAS号：29908-03-0

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S-Adenosyl-L-methionine 纯度/质量文件产品仅供科研

货号：A132774 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

S-Adenosyl-L-methionine 生物活性

描述	Ademetionine is a naturally-occurring substance which is a major source of methyl groups in the brain.

S-Adenosyl-L-methionine 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03472820	Lifestyle Die... 展开 >>t Healthy 收起 <<	Not Applicable	Recruiting	April 1, 2019	United States, Oregon ... 展开 >> NUNM Helfgott Research Institute Recruiting Portland, Oregon, United States, 97201 Contact: Trina Soileau Research Coordinator 503-552-1746 tsoileau@nunm.edu Contact: Emily Stack Research Coordinator 503-552-1777 estack@nunm.edu Principal Investigator: Ryan Bradley, ND, MPH 收起 <<
NCT02649777	-		Completed	-	United States, Colorado ... 展开 >> Children's Hospital Colorado Aurora, Colorado, United States, 80045 收起 <<
NCT03435250	Advanced Solid Tumors ... 展开 >> Lymphoma 收起 <<	Phase 1	Recruiting	October 2020	United States, Connecticut ... 展开 >> New Haven Recruiting New Haven, Connecticut, United States, 06519 United States, Massachusetts Boston Recruiting Boston, Massachusetts, United States, 02114 United States, New York New York Recruiting New York, New York, United States, 10065 United States, Tennessee Nashville Recruiting Nashville, Tennessee, United States, 37203 France Villejuif Cedex Not yet recruiting Villejuif Cedex, France, 94805 Spain Barcelona Not yet recruiting Barcelona, Spain, 08035 收起 <<

S-Adenosyl-L-methionine 参考文献

[1]Najm WI, Reinsch S, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495] . BMC Musculoskelet Disord. 2004 Feb 26;5:6.

[2]Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.

S-Adenosyl-L-methionine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.55mL

2.51mL

1.25mL

25.10mL

5.02mL

2.51mL

S-Adenosyl-L-methionine 技术信息

CAS号	29908-03-0
分子式	C₁₅H₂₂N₆O₅S
分子量	398.44
SMILES Code	O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3C[S+](CC[C@H](N)C([O-])=O)C
MDL No.	MFCD00871208

别名	S-腺苷-L-甲硫氨酸;S-腺苷甲硫氨酸 ;S-Adenosyl methionine; AdoMet; Gumbaral.; S-adenosylmethionine. Heptral; MSI-195; SAMe; Ademetionine; SAM
运输	蓝冰
InChI Key	MEFKEPWMEQBLKI-AIRLBKTGSA-N
Pubchem ID	34755

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, store in freezer, under -20°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(263.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 45 mg/mL(112.94 mM)

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03472820	Lifestyle Die... 展开 >>t Healthy 收起 <<	Not Applicable	Recruiting	April 1, 2019	United States, Oregon ... 展开 >> NUNM Helfgott Research Institute Recruiting Portland, Oregon, United States, 97201 Contact: Trina Soileau Research Coordinator 503-552-1746 tsoileau@nunm.edu Contact: Emily Stack Research Coordinator 503-552-1777 estack@nunm.edu Principal Investigator: Ryan Bradley, ND, MPH 收起 <<
NCT02649777	-		Completed	-	United States, Colorado ... 展开 >> Children's Hospital Colorado Aurora, Colorado, United States, 80045 收起 <<
NCT03435250	Advanced Solid Tumors ... 展开 >> Lymphoma 收起 <<	Phase 1	Recruiting	October 2020	United States, Connecticut ... 展开 >> New Haven Recruiting New Haven, Connecticut, United States, 06519 United States, Massachusetts Boston Recruiting Boston, Massachusetts, United States, 02114 United States, New York New York Recruiting New York, New York, United States, 10065 United States, Tennessee Nashville Recruiting Nashville, Tennessee, United States, 37203 France Villejuif Cedex Not yet recruiting Villejuif Cedex, France, 94805 Spain Barcelona Not yet recruiting Barcelona, Spain, 08035 收起 <<
NCT02812121	Liver Failure	Phase 2	Unknown	June 2018	-
NCT03535675	Adenocarcinoma of the Prostate	Phase 3	Recruiting	December 2021	United States, District of Col... 展开 >>umbia Sibley Memorial Hospital Recruiting Washington, District of Columbia, United States, 20016 Contact: Channing Paller, MD 202-660-6500 cpaller1@jhmi.edu United States, Maryland Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21205 Contact: Donna Dowling, RN 410-614-9526 ddowlin1@jhmi.edu Principal Investigator: Channing Paller, MD 收起 <<
NCT01964001	Hepatocellular Carcinoma.	Phase 2 Phase 3	Completed	-	Taiwan ... 展开 >> Taichung Verterans General Hospital Taichung, Taiwan, 40705 收起 <<
NCT00903695	-		Terminated(Risk/benefit ratio ... 展开 >>did not indicate further study would be useful, or fair to future subjects.) 收起 <<	-	-
NCT02062892	Kidney Transplantation	Phase 4	Withdrawn(Patients meeting the... 展开 >> inclusion/ exclusion criteria did not agree to participate. It became obvious that recruitment goals could not be met.) 收起 <<	-	-
NCT01320527	Alzheimer's Disease ... 展开 >> Mild Cognitive Impairment 收起 <<	Phase 2	Completed	-	United States, Florida ... 展开 >> Naples Medical Center Naples, Florida, United States, 34102 United States, Maryland University of Maryland Baltimore, Maryland, United States, 21201 United States, Massachusetts Primary Care Cardiology Research Ayer, Massachusetts, United States, 01432 Rivercourt Residences Groton, Massachusetts, United States, 014590 Mary Immaculate Residential Lawrence, Massachusetts, United States, 01841 D'Youville Senior Care Lowell, Massachusetts, United States, 01854 United States, New Jersey Neurocognitive Institute Mt. Arlington, New Jersey, United States, 07856 United States, Utah Advanced Memory Dynamics Layton, Utah, United States, 84040 收起 <<
NCT01844063	Liver Failure	Phase 1 Phase 2	Recruiting	January 2019	China, Guangdong ... 展开 >> Qi Zhang Recruiting Guangzhou, Guangdong, China, 510630 Principal Investigator: Qi Zhang, Doctor 收起 <<
NCT01749982	-		Completed	-	-
NCT01360723	-		Unknown	-	Taiwan ... 展开 >> Department of Urology, China Medical University Hospital Recruiting Taichung, Taiwan, 404 Contact: Chao-Hsiang Chuang, PhD 886-4-22052121 ext 4439 urology8395@yahoo.com.tw Principal Investigator: Chi-Jung Chung, PhD 收起 <<
NCT02264860	HIV-1 Infection	Not Applicable	Recruiting	December 2018	United States, Georgia ... 展开 >> Ponce De Leon Center Recruiting Atlanta, Georgia, United States, 30308 Contact: Vincent Marconi, MD 404-616-0673 vcmarco@emory.edu Principal Investigator: David M Guidot, MD 收起 <<
NCT00956891	-		Completed	-	China, Guangdong ... 展开 >> The Third Affiliated Hospital Of Sun Yat-sen University Guangzhou, Guangdong, China, 510630 收起 <<
NCT01806870	HIV	Not Applicable	Active, not recruiting	June 2019	United States, Georgia ... 展开 >> Grady Hospital- Ponce De Leon Clinic Atlanta, Georgia, United States, 30308 Atlanta VA Medical Center Decatur, Georgia, United States, 30033 收起 <<
NCT02022046	-		Completed	-	Taiwan ... 展开 >> Kaohsiung Chang Gung Memorial Hospital Kaohsiung, Taiwan, 833 收起 <<
NCT02331745	Liver Failure ... 展开 >> Hepatitis B Alcoholic Liver Disease 收起 <<	Phase 4	Unknown	October 2016	China ... 展开 >> Beijing; 302 Military Hospital Recruiting Beijing, China, 100039 Contact: Jinbiao Ding, Dr. 86106693462 dingjb163@163.com 收起 <<
NCT01749982	Arsenic Metabolites Measured i... 展开 >>n Urine 收起 <<	Phase 4	Completed	-	Bangladesh ... 展开 >> Columbia University Arsenic Research Project Dhaka, Bangladesh 收起 <<
NCT00070941	-		Completed	-	-
NCT00903695	Mild Cognitive Impairment	Phase 2	Terminated(Risk/benefit ratio ... 展开 >>did not indicate further study would be useful, or fair to future subjects.) 收起 <<	-	United States, Oklahoma ... 展开 >> Univ. of Okla. Health Sciences Center & VAMC OKC Oklahoma City, Oklahoma, United States, 73104 Veterans Affairs Medical Center Oklahoma City, Oklahoma, United States, 73104 收起 <<
NCT02520206	-		Unknown	August 2015	-
NCT03266146	Drug-induced Liver Injury,Chro... 展开 >>nic 收起 <<	Phase 1 Phase 2	Recruiting	August 27, 2021	China ... 展开 >> Beijing 302 hospital Recruiting Beijing, China, 100039 Contact: Zhengsheng Zou, Dr. +8601066933424 zszou302@163.com Principal Investigator: Zhengsheng Zou, Dr. 收起 <<
NCT00513461	Adult Primary Liver Cancer ... 展开 >> Hepatitis C Infection 收起 <<	Phase 2	Completed	-	United States, Arizona ... 展开 >> University of Arizona Health Sciences Center Tucson, Arizona, United States, 85724 United States, California Veterans Administration Long Beach Medical Center Long Beach, California, United States, 90822 Veterans Administration Los Angeles Healthcare System Los Angeles, California, United States, 90073 Chao Family Comprehensive Cancer Center Orange, California, United States, 92868 University of California At San Diego San Diego, California, United States, 92103 收起 <<
NCT00070941	Parkinson's Disease ... 展开 >> Depression 收起 <<	Phase 2 Phase 3	Completed	-	United States, New York ... 展开 >> New York University New York, New York, United States, 10003 收起 <<
NCT02651350	Drug-induced Liver Injury,Chro... 展开 >>nic 收起 <<	Phase 1 Phase 2	Active, not recruiting	December 2019	China, Beijing ... 展开 >> Beijing 302 hospital,China Beijing, Beijing, China, 100039 收起 <<
NCT01912196	Major Depressive Disorder (MDD... 展开 >>) 收起 <<	Phase 2	Completed	-	-
NCT01754714	Non Alcoholic Fatty Liver Dise... 展开 >>ase 收起 <<	Phase 3	Completed	-	France ... 展开 >> Site Reference ID 93914 Amiens, France, 80054 Site Reference ID 93895 Angers, France, 49933 Site Reference ID 93894 Bobigny, France, 93009 Site Reference ID 93913 Montpellier, France, 34295 Site Reference ID 93916 Nice, France, 06202 Site Reference ID 93915 Paris, France, 75012 Site Reference ID 93893 Paris, France, 75651 Site Reference ID 93896 Pessac, France, 33604 Germany Site Reference ID 93953 Bonn, Germany, 53127 Site Reference ID 93954 Frankfurt, Germany, 60594 Site Reference ID 93935 Freiburg, Germany, 79106 Site Reference ID 93955 Halle, Germany, 06120 Site Reference ID 93917 Hannover, Germany, 30625 Site Reference ID 93933 Homburg, Germany, 66424 Site Reference ID 94015 Leipzig, Germany, 04103 Site Reference ID 93918 Mainz, Germany, 55131 Site Reference ID 94014 Ulm, Germany, 89081 Poland Site reference ID/Investigator # 109455 Bydgoszcz, Poland, 85-030 Site Reference ID 93958 Chorzow, Poland, 41-500 Site Reference ID 93973 Krakow, Poland, 31-531 Site Reference ID 93956 Lodz, Poland, 91-347 Site Reference ID 93957 Myslowice, Poland, 41-400 Site Reference ID 93974 Warsaw, Poland, 02-507 Site Reference ID 93975 Wroclaw, Poland, 50-220 Russian Federation Site reference ID ORG-000905 Krasnoyarsk, Russian Federation, 660022 Site reference ID ORG-000906 Moscow, Russian Federation, 119435 Site reference ID ORG-000900 Nizhniy Novgorod, Russian Federation, 603126 Site reference ID ORG-000907 Novosibirsk, Russian Federation, 630084 Site reference ID ORG-000903 Omsk, Russian Federation, 644043 Site reference ID ORG-000920 Rostov-on-Don, Russian Federation, 344022 Site reference ID ORG-000904 Samara, Russian Federation, 443011 Site reference ID ORG-000901 Stavropol, Russian Federation, 355017 收起 <<
NCT00513461	-		Completed	-	-
NCT00093847	-		Completed	-	-
NCT00851981	Alcoholic Hepatitis	Phase 2	Completed	-	United States, California ... 展开 >> Loma Linda University Loma Linda, California, United States, 92354 收起 <<
NCT00284011	Heart Disease	Not Applicable	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic Rochester, Minnesota, United States, 55905 收起 <<
NCT01754714	-		Completed	-	-
NCT00762268	Bipolar Disorder ... 展开 >> Depression Bipolar Depression 收起 <<	Not Applicable	Completed	-	United States, Massachusetts ... 展开 >> McLean Hospital Belmont, Massachusetts, United States, 02478 收起 <<
NCT00762268	-		Completed	-	-
NCT00125281	Liver Cirrhosis, Biliary	Phase 2	Terminated	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT00093847	Depression	Phase 2	Completed	-	United States, Massachusetts ... 展开 >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 收起 <<
NCT01140646	Healthy, no Evidence of Diseas... 展开 >>e Hot Flashes 收起 <<	Phase 2	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic Rochester, Minnesota, United States, 55905 收起 <<
NCT02024295	Hepatitis, Alcoholic	Phase 4	Unknown	December 2015	China, Beijing ... 展开 >> Beijing Ditan Hospital Recruiting Beijing, Beijing, China, 100015 Contact: Jun Cheng 8610-84322566 jun.cheng.ditan@gmail.com Jun Cheng Recruiting Beijing, Beijing, China, 100015 Contact: Jun Cheng 收起 <<
NCT00573313	-		Completed	-	-
NCT01899521	Alcoholism	Not Applicable	Completed	-	United States, Georgia ... 展开 >> Atlanta VA Medical and Rehab Center, Decatur, GA Decatur, Georgia, United States, 30033 收起 <<
NCT00573313	Liver Disease, Alcoholic	Phase 3	Completed	-	United States, California ... 展开 >> University of California, Davis Medical Center Sacramento, California, United States, 95817 收起 <<
NCT03178929	Primary Liver Cancer	Not Applicable	Not yet recruiting	August 31, 2020	-
NCT00722124	Tobacco Dependence	Phase 2 Phase 3	Completed	-	United States, Minnesota ... 展开 >> Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Wisconsin Franciscan Skemp HealthCare La Crosse, Wisconsin, United States, 54601 收起 <<
NCT01140646	-		Completed	-	-
NCT00722124	-		Completed	-	-
NCT00101452	-		Completed	-	-
NCT00101452	Depression	Not Applicable	Completed	-	United States, Massachusetts ... 展开 >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Rhode Island Butler Hospital Providence, Rhode Island, United States, 02906 收起 <<
NCT00475176	Chronic Hepatitis C	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT00310336	Hepatitis C	Phase 2 Phase 3	Completed	-	Switzerland ... 展开 >> University Hospital Basel Basel, BS, Switzerland, 4031 收起 <<
NCT00475176	-		Completed	-	-
NCT00694564	Abdominal Pain	Not Applicable	Completed	-	United States, California ... 展开 >> University of California, San Diego San Diego, California, United States, 92103 收起 <<
NCT00694564	-		Completed	-	-
NCT02231333	Non-alcoholic Steatohepatitis	Not Applicable	Unknown	June 2016	India ... 展开 >> Institute of Liver & Biliary Sciences Recruiting New Delhi, Delhi, India, 110070 Contact: Dr Devraj K, MD 011-46300000 drdevurgowda@gmail.com 收起 <<
NCT00473200	Hyperhomocysteinemia	Phase 1	Completed	-	United States, Texas ... 展开 >> Baylor University Medical Center Dallas, Texas, United States, 75204 收起 <<
NCT01998620	Hepatitis B C... 展开 >>holestasis 收起 <<	Phase 4	Unknown	May 2015	China, Shanghai ... 展开 >> Public Health Clinical Center Affiliated to Fudan University Recruiting Shanghai, Shanghai, China, 200000 Contact: Liang Chen, Doctor 00862137990333 chenlian@shaphl.org 收起 <<
NCT00528710	Fibromyalgia Syndrome	Phase 2	Completed	-	Australia, Victoria ... 展开 >> Deakin University Burwood, Victoria, Australia, 3125 收起 <<
NCT02200029	Intrahepatic Cholestasis Assoc... 展开 >>iated With Alcoholic Liver Disease 收起 <<	Phase 3	Completed	-	Russian Federation ... 展开 >> Research facility ORG-000962 Moscow, Russian Federation, 107014 Research facility ORG-000957 Moscow, Russian Federation, 117292 Research facility ORG-000961 Moscow, Russian Federation, 119435 Research facility ID ORG-000960 Moscow, Russian Federation, 119992 Research facility ID ORG-000726 Moscow, Russian Federation, 125284 Research facility ORG-000967 St. Petersburg, Russian Federation, 117630 Research facility ORG-000966 St. Petersburg, Russian Federation, 191015 Research facility ORG-000968 St. Petersburg, Russian Federation, 195257 Research facility ORG-000965 St. Petersburg, Russian Federation, 197022 Research facility ORG-000970 St. Petersburg, Russian Federation, 198216 Research facility ORG-000958 Troitsk, Russian Federation, 142190 Research facility ORG-000969 Yaroslavl, Russian Federation, 150003 收起 <<
NCT00108589	Hepatitis	Phase 3	Completed	-	United States, Kentucky ... 展开 >> VA Medical Center Louisville, Kentucky, United States, 40206 收起 <<
NCT02557360	Primary Biliary Cirrhosis	Phase 4	Completed	-	Poland ... 展开 >> Wunsch Szczecin, Poland Milkiewicz Warsaw, Poland 收起 <<
NCT02586285	Hepatocellular Carcinoma	Phase 1	Unknown	December 2017	China, Shanghai ... 展开 >> Eastern hepatobilliary surgery hospital Recruiting Shanghai, Shanghai, China, 200438 Contact: Shen Feng, MD 0086-021-25070805 shenfengdfgd@yahoo.com.cn Contact: Yong Xia, Doctor 86-021-81875495 Principal Investigator: Shen Feng, MD 收起 <<

S-Adenosyl-L-methionine {[allProObj[0].p_purity_real_show]}

S-Adenosyl-L-methionine 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

S-Adenosyl-L-methionine 质控信息

S-Adenosyl-L-methionine 生物活性

S-Adenosyl-L-methionine 临床研究

S-Adenosyl-L-methionine 参考文献

S-Adenosyl-L-methionine 实验方案

S-Adenosyl-L-methionine 技术信息

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S-Adenosyl-L-methionine {[allProObj[0].p_purity_real_show]}

S-Adenosyl-L-methionine 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

S-Adenosyl-L-methionine 质控信息

S-Adenosyl-L-methionine 生物活性

S-Adenosyl-L-methionine 临床研究

S-Adenosyl-L-methionine 参考文献

S-Adenosyl-L-methionine 实验方案

S-Adenosyl-L-methionine 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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