S-Adenosyl-L-methionine

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Chemical Structure| 29908-03-0 同义名 : S-腺苷-L-甲硫氨酸;S-腺苷甲硫氨酸 ;S-Adenosyl methionine; AdoMet; Gumbaral.; S-adenosylmethionine. Heptral; MSI-195; SAMe; Ademetionine; SAM
CAS号 : 29908-03-0
货号 : A132774
分子式 : C15H22N6O5S
纯度 : 98%
分子量 : 398.44
MDL号 : MFCD00871208
存储条件:

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(263.53 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 45 mg/mL(112.94 mM)

生物活性
描述 Ademetionine is a naturally-occurring substance which is a major source of methyl groups in the brain.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03472820 Lifestyle Die... 展开 >>t Healthy 收起 << Not Applicable Recruiting April 1, 2019 United States, Oregon ... 展开 >> NUNM Helfgott Research Institute Recruiting Portland, Oregon, United States, 97201 Contact: Trina Soileau Research Coordinator    503-552-1746    tsoileau@nunm.edu    Contact: Emily Stack Research Coordinator    503-552-1777    estack@nunm.edu    Principal Investigator: Ryan Bradley, ND, MPH 收起 <<
NCT02649777 - Completed - United States, Colorado ... 展开 >> Children's Hospital Colorado Aurora, Colorado, United States, 80045 收起 <<
NCT03435250 Advanced Solid Tumors ... 展开 >> Lymphoma 收起 << Phase 1 Recruiting October 2020 United States, Connecticut ... 展开 >> New Haven Recruiting New Haven, Connecticut, United States, 06519 United States, Massachusetts Boston Recruiting Boston, Massachusetts, United States, 02114 United States, New York New York Recruiting New York, New York, United States, 10065 United States, Tennessee Nashville Recruiting Nashville, Tennessee, United States, 37203 France Villejuif Cedex Not yet recruiting Villejuif Cedex, France, 94805 Spain Barcelona Not yet recruiting Barcelona, Spain, 08035 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.55mL

2.51mL

1.25mL

25.10mL

5.02mL

2.51mL

参考文献

[1]Najm WI, Reinsch S, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495] . BMC Musculoskelet Disord. 2004 Feb 26;5:6.

[2]Bressa GM. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.