(+)-Pteryxin, a natural product isolated and purified from the herbs of Peucedanum harry-smithii var. subglabrum, has muscle-relaxant property and shows hepatoprotective and nitric oxide prodn. inhibitory activity.
Pteryxin/北美芹素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Mouse insulinoma MIN6 cells
Mouse insulinoma MIN6 cells
To evaluate the protective effect of Pteryxin on MIN6 cells under H2O2-induced oxidative stress, results showed enhanced expression of GCLC, Trxr1, and HO-1 antioxidant enzymes.
Antioxidants (Basel). 2023 Mar 10;12(3):693.
Mouse insulinoma MIN6 cells
Mouse insulinoma MIN6 cells
To investigate the effect of Pteryxin on gene expression in the ARE region, results showed significant increases in the expression of HO-1, GCLC, SOD1, Srxn1, and Trxr1 genes.
Antioxidants (Basel). 2023 Mar 10;12(3):693.
Mouse insulinoma MIN6 cells
Mouse insulinoma MIN6 cells
To evaluate the cytotoxicity of Pteryxin on MIN6 cells, results showed no cytotoxicity was observed in the range of the test concentrations.
Antioxidants (Basel). 2023 Mar 10;12(3):693.
RAW264.7 cells
RAW264.7 cells
To evaluate the activation of Nrf2-ARE signaling by Pteryxin, results showed that Pteryxin significantly induced Nrf2 activity and promoted HO-1 protein expression.
Antioxidants (Basel). 2019 Dec 5;8(12):621.
Pteryxin/北美芹素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Zebrafish larvae
PTZ-induced seizure-like behavior model
Immersion
20 µM
1 hour and 18 hours
PTX significantly inhibited PTZ-induced seizure-like movements after 1 h and 18 h of immersion, with efficacy comparable to VPN. The anticonvulsive effect of PTX was confirmed by local field potential (LFP) recordings.
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