Pocapavir, also known as SCH-48973, is an orally active capsid inhibitor. Pocapavir prevents viruses from entering cells and then unencapsulating them. Pocapavir has antiviral activity against poliovirus and also inhibits enteroviral infections[1].Pocapavir belongs to a group of picornavirus antiviral mechanisms that prevent viral replication by preventing viral uncoating and release of viral RNA into cells[2].
Pocapavir 细胞实验
Cell Line
Concentration
Treated Time
Description
References
BGMK cells
0.02 to 0.11 µg/ml
18 to 24 hours
To evaluate the inhibitory effect of SCH 48973 on echoviruses, results showed significant antiviral activity.
To evaluate the inhibitory effect of SCH 48973 on the cytopathic effect of five picornaviruses, results showed significant antiviral activity with no cytotoxicity.
To evaluate the therapeutic efficacy of SCH 48973 in a mouse poliovirus model, results showed significant improvement in survival and reduction in brain viral titers.
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