When administered via oral gavage at doses ranging from 50 mg/kg to 200 mg/kg daily for five consecutive days, starting two weeks post-infection, paromomycin sulfate significantly reduces the count of oocysts per gram of feces and in the intestines. Histological examination reveals minimal focal inflammation in only 20% of intestinal sections from mice infected with C. parvum at a dose of 50 mg/kg and only 10% focal inflammation at 200 mg/kg, indicating its efficacy and relative safety at these dosages^[1].

In cell culture studies, paromomycin sulfate at a concentration of 500 μg/ml dramatically reduces intracellular parasitic forms by 97.2% in Caco-2 cells and by 99.5% in HCT-8 cells relative to control, demonstrating its effectiveness against intracellular parasites^[2].