Paromomycin Sulfate

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Chemical Structure| 1263-89-4 同义名 : 硫酸巴龙霉素 ;Aminosidine sulfate; Paromomycin (sulfate)
CAS号 : 1263-89-4
货号 : A1364665
分子式 : C23H47N5O18S
纯度 : 675 μg/mg
分子量 : 713.71
MDL号 : MFCD00079278
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 100 mg/mL(140.11 mM)，配合低频超声，并水浴加热至45℃助溶
生物活性
描述 Paromomycin sulfate is a derivative of neomycin, is a broad-spectrum aminoglycoside antibiotic noted for its amebicidal and bactericidal properties. It binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, leading to premature termination of mRNA translation and inhibition of protein synthesis. This makes paromomycin sulfate suitable for research on bacterial and parasitic infections.[1][2][3]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.40mL

0.28mL

0.14mL

7.01mL

1.40mL

0.70mL

14.01mL

2.80mL

1.40mL
参考文献

[1]Tony J Tavares, et al. Structure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin. RNA. 2009 May;15(5):911-22.

[2]Mohamed Mammeri, et al. Efficacy of chitosan, a natural polysaccharide, against Cryptosporidium parvum in vitro and in vivo in neonatal mice. Exp Parasitol. 2018 Nov;194:1-8.

[3]Ibrahim Aly, et al. Efficacy of Low and High Dose of Paromomycin Sulfate for Treatment of Cryptosporidiosis in Immunosuppressed Infected-Mice.Global Veterinaria 15 (2): 137-143, 2015