PKG drug G1 {[allProObj[0].p_purity_real_show]}

PKG drug G1 质控信息

PKG drug G1 生物活性

描述	PKG Drug G1 targets C42 of PKG Iα. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.

PKG drug G1 细胞实验

Cell Line Rat aortic smooth muscle cells	Concentration	Treated Time	Description	References
Rat aortic smooth muscle cells	10 or 50 mM	10 minutes	To evaluate the effect of G1 on VASP phosphorylation. G1 alone did not alter VASP phosphorylation but synergistically enhanced it when co-administered with 8-Br-cGMP.	Hypertension. 2017 Sep;70(3):577-586
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PKG drug G1 动物实验

Species Mice	Animal Model Angiotensin II-induced hypertension model	Administration	Dosage	Frequency	Description	References
Mice	Angiotensin II-induced hypertension model	Intraperitoneal or oral	3.7–14.8 mg/kg (intraperitoneal) or 20 mg/kg (oral)	Single dose or continuous administration for 4 days	To evaluate the antihypertensive effect of G1 in a hypertension model. G1 effectively lowered blood pressure in WT mice but had no effect in C42S PKG Iα knock-in mice.	Hypertension. 2017 Sep;70(3):577-586
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PKG drug G1 实验方案

计算器	摩尔计算器 总药量计算器 工作液计算器
存储液制备		1mg	5mg	10mg
	1 mM 5 mM 10 mM	3.89mL 0.78mL 0.39mL	19.43mL 3.89mL 1.94mL	38.86mL 7.77mL 3.89mL

PKG drug G1 技术信息