货号:A615114
同义名:
Sophoridine N-oxide
Oxysophoridine 是从狼毒(Sophora alopecuroidos L.)中分离的天然产物,可抑制小鼠脑皮层中 N-甲基-D-天冬氨酸 NR1 mRNA 和蛋白表达,常用于脑缺血/再灌注损伤的研究。
HazMat Fee + There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
| Type | HazMat fee for 500 gram (Estimated) |
| Excepted Quantity | USD 0.00 |
| Limited Quantity | USD 15-60 |
| Inaccessible (Haz class 6.1), Domestic | USD 80+ |
| Inaccessible (Haz class 6.1), International | USD 150+ |
| Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
| Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |


| 规格 | 价格 | 会员价 | 库存 | 数量 | |||
|---|---|---|---|---|---|---|---|
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解

| 产品名称 | NMDA receptor ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kynurenic acid | ✔ | 97% | |||||||||||||||||
| Dizocilpine maleate |
+++
NMDA receptor, Kd: 37.2 nM |
99%+ | |||||||||||||||||
| Felbamate |
+
NMDAR, IC50: 1.8 mM |
98% | |||||||||||||||||
| (-)-Dizocilpine maleate |
++++
NMDA receptor, Ki: 30.5 nM |
98% | |||||||||||||||||
| Ifenprodil tartrate |
+++
NMDA Receptor, IC50: 0.3 μM |
98% | |||||||||||||||||
| Spermidine | ✔ | Autophagy | 98% GC | ||||||||||||||||
| 1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 | |||||||||||||||||||
| 描述 | Oxysophoridine is a natural product isolated and purified from the herb of Sophora alopecuroidos L. with a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms. Oxysophoridine ameliorates cardiac damage in a rat model of AMI and that this cardioprotection may be linked with its anti-oxidative, anti-apoptotic and anti-inflammatory properties. Oxysophoridine may be a potential neuroprotective agent for cerebral ischemia injury, that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. |
| 计算器 | ||||
| 存储液制备 | ![]() |
1mg | 5mg | 10mg |
|
1 mM 5 mM 10 mM |
3.78mL 0.76mL 0.38mL |
18.91mL 3.78mL 1.89mL |
37.83mL 7.57mL 3.78mL |
|
| CAS号 | 54809-74-4 |
| 分子式 | C15H24N2O2 |
| 分子量 | 264.36 |
| SMILES Code | O=C1CCC[C@]2([H])[C@@]3([H])CCC[N+]4([O-])[C@@]3([H])[C@@](CCC4)([H])CN21 |
| MDL No. | MFCD00210339 |
| 别名 | Sophoridine N-oxide |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
| 溶解方案 |
DMSO: 25 mg/mL(94.57 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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