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Oleic acid/油酸 {[allProObj[0].p_purity_real_show]}

货号：A387371 同义名： (9Z)-9-十八烯酸 / 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid

Oleic acid是一种天然存在于多种动物和植物脂肪及油脂中的脂肪酸。它也作为 Na+/K+ ATP 酶的激活剂使用。

Oleic acid/油酸 化学结构 CAS号：112-80-1
Oleic acid/油酸 化学结构
CAS号：112-80-1
Oleic acid/油酸 3D分子结构
CAS号：112-80-1
Oleic acid/油酸 化学结构 CAS号：112-80-1
Oleic acid/油酸 3D分子结构 CAS号：112-80-1
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Oleic acid/油酸 纯度/质量文件 产品仅供科研

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全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
更多 >

Oleic acid/油酸 生物活性

描述 Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is also used as an activator of Na+/K+ ATPase.

Oleic acid/油酸 细胞实验

Cell Line
Concentration Treated Time Description References
HepG2 cells 300 mM 24 hours To investigate the effect of apelin/APLNR on hepatic lipid accumulation. Results showed that apelin/APLNR did not directly affect lipid metabolism in hepatocytes. Int J Med Sci. 2025 Jan 1;22(1):197-208.
L02 cells 400 µM 2 and 5 days To evaluate the cytotoxicity and lipid droplet accumulation effects of OA on L02 cells. Results showed that OA had no significant cytotoxicity in 2 days but slight cytotoxicity at 400 µM in 5 days. Lipid droplet accumulation increased in a time-dependent manner within 5 days. Int J Mol Sci. 2024 May 7;25(10):5086.
HepG2 cells 400 µM 2 and 5 days To evaluate the cytotoxicity and lipid droplet accumulation effects of OA on HepG2 cells. Results showed that OA had no significant cytotoxicity in 2 days but slight cytotoxicity at 400 µM in 5 days. Lipid droplet accumulation increased in a time-dependent manner within 5 days. Int J Mol Sci. 2024 May 7;25(10):5086.
H1299 20 nM 48 hours To evaluate the effect of OA on radioresistant cells, OA pretreatment significantly reduced radiation-induced lipid ROS and iron accumulation, increased the GSH/GSSG ratio, and protected cells from radiation-induced ferroptosis. Cell Death Dis. 2025 Mar 18;16(1):184
A549 20 nM 48 hours To evaluate the effect of OA on radioresistant cells, OA pretreatment significantly reduced radiation-induced lipid ROS and iron accumulation, increased the GSH/GSSG ratio, and protected cells from radiation-induced ferroptosis. Cell Death Dis. 2025 Mar 18;16(1):184
CMT93 20 nM 48 hours To evaluate the effect of OA on radioresistant cells, OA pretreatment significantly reduced radiation-induced lipid ROS and iron accumulation, increased the GSH/GSSG ratio, and protected cells from radiation-induced ferroptosis. Cell Death Dis. 2025 Mar 18;16(1):184
SW837 20 nM 48 hours To evaluate the effect of OA on radioresistant cells, OA pretreatment significantly reduced radiation-induced lipid ROS and iron accumulation, increased the GSH/GSSG ratio, and protected cells from radiation-induced ferroptosis. Cell Death Dis. 2025 Mar 18;16(1):184
DRG neurons 5 μM 5 min Inhibited capsaicin-activated currents by 86.6±4% Nat Commun. 2016 Oct 10;7:13092.
HEK293 cells 5 μM 5 min Inhibited thermally activated TRPV1 currents by 72±8% Nat Commun. 2016 Oct 10;7:13092.
AML12 cells 400 μM 18 hours AGPAT2 deficiency led to the formation of giant LDs Nat Commun. 2021 Nov 25;12(1):6877.
LY2 cells 100 μmol/L 24 hours To evaluate the effect of oleic acid and fenofibrate on LY2 cell viability, results showed increased intrinsic cancer cell toxicity upon treatment with FF or OA. Clin Cancer Res. 2024 May 1;30(9):1916-1933.
MOC2 cells 100 μmol/L 24 hours To evaluate the effect of oleic acid and fenofibrate on MOC2 cell viability, results showed increased intrinsic cancer cell toxicity upon treatment with FF or OA. Clin Cancer Res. 2024 May 1;30(9):1916-1933.
Vascular smooth muscle cells (VSMC) 2.5 μmol/L 10 minutes To evaluate the effect of OA-NO2 on Ang II-induced IP3 production and calcium mobilization, results showed OA-NO2 inhibits Ang II-induced IP3 production and calcium mobilization Circ Res. 2010 Aug 20;107(4):540-8.
HEK293 cells 5 μmol/L 3 hours To detect covalent binding of OA-NO2 to AT1R, results showed OA-NO2 forms covalent adducts with AT1R Circ Res. 2010 Aug 20;107(4):540-8.
Human Dermal Micovasvular Endothelial Cells (HDMEC) 1mM Overnight HDMEC were cultured on transwell inserts to form compact monolayers. OA loading induced LD formation. In the experiment, LD-rich HDMEC were co-cultured with differentiated C2C12 myotubes, and free fatty acid release was detected. Circ Res. 2017 Apr 14;120(8):1289-1297.
EA.hy 926 cells 1mM Overnight In EA.hy 926 cells, RT-qPCR analysis showed that only PLN2 and PLN3 among the 5 known perilipins (PLN) were expressed. Subcellular fractionation revealed that LD fractions were enriched with PLN2, PLN3, and lipolytic enzymes including ATGL and its co-activator CGI-58. Circ Res. 2017 Apr 14;120(8):1289-1297.
Mouse lung endothelial cells (MLEC) 1mM 24 hours OA-induced LD formation in MLEC was time- and dose-dependent, reaching maximum cellular TG content (285.86±41.05 nmol TG/mg protein) after 24 hours. OA supplementation increased mRNA levels of TG synthetic enzymes including GPAT4, AGPAT2, Lipin2, DGAT1, and DGAT2. Circ Res. 2017 Apr 14;120(8):1289-1297.
Mouse melanoma cells 500 μM 12 hours Oleic acid protected melanoma cells from Erastin-induced ferroptosis Nature. 2020 Sep;585(7823):113-118.
Human melanoma cells 500 μM 12 hours Oleic acid protected melanoma cells from Erastin-induced ferroptosis Nature. 2020 Sep;585(7823):113-118.
Human Dermal Microvascular Endothelial Cells (HDMEC) 1mM Overnight To study lipid droplet formation and fatty acid release, results showed that OA treatment induced lipid droplet formation and fatty acid release was affected by inhibition of ATGL and HSL. Circ Res. 2017 Apr 14;120(8):1289-1297.
EA.hy 926 cells 1mM Overnight To study the expression of lipid droplet-associated proteins, results showed that PLN2 and PLN3 were expressed in EA.hy 926 cells and enriched in the lipid droplet fraction. Circ Res. 2017 Apr 14;120(8):1289-1297.
Mouse lung endothelial cells (MLEC) 1mM 24 hours To study oleic acid-induced lipid droplet formation and its time-dependence, results showed that cellular triglyceride content reached maximum after 24 hours of OA treatment. Circ Res. 2017 Apr 14;120(8):1289-1297.
Primary hepatocytes 2 mM 8 hours To evaluate OA-induced lipid accumulation and the alleviating effect of metformin. Results showed that OA significantly increased intracellular lipid accumulation, while metformin pretreatment significantly attenuated OA-induced lipid accumulation. Autophagy. 2015;11(1):46-59.
HepG2 cells 1 mM 8 hours To evaluate OA-induced lipid accumulation and the alleviating effect of metformin. Results showed that OA significantly increased intracellular lipid accumulation, while metformin pretreatment significantly attenuated OA-induced lipid accumulation. Autophagy. 2015;11(1):46-59.

Oleic acid/油酸 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
C57Bl/6 mice Acute lung injury model Intravenous injection 0.15 µl/g Single dose, observed for 24 hours Oleic acid caused severe alveolar damage with the development of alveolar edema of the increased-permeability type with associated abnormalities in gas exchange. When given together with endotoxin, they acted synergistically to increase pulmonary edema and to worsen gas exchange and hemodynamics, thereby increasing mortality. Am J Respir Crit Care Med. 2005 Aug 1;172(3):344-51
C57BL/6 mice Fasted mice gavaged with olive oil Oral gavage 10mL/kg Single gavage, observation time points included 90 mins, 180 mins, and 270 mins To study the dynamics of oleic acid-induced lipid droplet formation and degradation, results showed that plasma triglyceride levels peaked at 90 mins post-gavage, lipid droplets were prominent in aortic endothelial cells at 180 mins, and degraded by 270 mins. Circ Res. 2017 Apr 14;120(8):1289-1297.
Mice Pain and itch models Plantar injection 3.1 μg/10 μl Single injection, observed for 10 min Significantly reduced pain responses induced by capsaicin and LPA Nat Commun. 2016 Oct 10;7:13092.
Mice Ang II-induced hypertension model Subcutaneous implantation of osmotic mini-pumps 5 mg/kg/day 14 days To evaluate the effect of OA-NO2 on Ang II-induced hypertension, results showed OA-NO2 significantly reduces Ang II-induced hypertension Circ Res. 2010 Aug 20;107(4):540-8.
NSG mice Patient-derived melanomas Intravenous injection 500 μM Single injection, observed for 1-3 months Pre-treatment with oleic acid significantly increased the metastatic potential of melanoma cells in the blood Nature. 2020 Sep;585(7823):113-118.

Oleic acid/油酸 动物研究

Animal study 急性肺损伤[3]
动物：SD大鼠，雄性，330-360 g。
给药：0.2 mg/kg，静脉注射，单次。
痤疮动物模型[4-5]
动物：SD 大鼠，雌雄皆可。
给药：取80%或100%油酸0.5 ml均匀涂抹于每只大鼠背部皮肤，连续涂抹14天，每天1次。

Oleic acid/油酸 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02646202 Gastroesophageal Varices Phase 3 Recruiting December 2021 Egypt ... 展开 >> Tropical medicine dept.-Tanta university hospital Recruiting Tanta, Egypt Contact: Sherief Abd-Elsalam       Sherif_tropical@yahoo.com 收起 <<
NCT02049034 Type 2 Diabetes Phase 4 Completed - United Kingdom ... 展开 >> University of Surrey FHMS Diabetes and Metabolic Medicine Guildford, Surrey, United Kingdom, GU2 7WG 收起 <<
NCT01931826 Schistosomiasis Mansoni ... 展开 >> Portal Hypertension Upper Gastrointestinal Bleeding 收起 << Not Applicable Completed - Brazil ... 展开 >> Universidade Federal de Alagoas Maceio, Alagoas, Brazil, 57000000 收起 <<

Oleic acid/油酸 参考文献

[1]Liu Z, Xiao Y, et al. Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells. Oncol Lett. 2013 Apr;5(4):1395-1399.

[2]Harvey KA, Walker CL, et al. Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. J Lipid Res. 2010 Dec;51(12):3470-80.

[3]Bueltmann M, Kong X, Mertens M, et al. Inhaled milrinone attenuates experimental acute lung injury. Intensive Care Med. 2009;35(1):171-178.

[4]Zuo T, Chen H, Xiang S, Hong J, Cao S, Weng L, Zhang L, Liu L, Li H, Zhu H, Liu Q. Cryptotanshinone-Loaded Cerasomes Formulation: In Vitro Drug Release, in Vivo Pharmacokinetics, and in Vivo Efficacy for Topical Therapy of Acne. ACS Omega. 2016 Dec 31;1(6):1326-1335. 

[5]Zhu Z, Chen T, Wang Z, Xue Y, Wu W, Wang Y, Du Q, Wu Y, Zeng Q, Jiang C, Shen C, Liu L, Zhu H, Liu Q. Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention. Front Pharmacol. 2021 Sep 1;12:700696.

Oleic acid/油酸 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.54mL

0.71mL

0.35mL

17.70mL

3.54mL

1.77mL

35.40mL

7.08mL

3.54mL

Oleic acid/油酸 技术信息

CAS号112-80-1
分子式C18H34O2
分子量 282.46
SMILES Code CCCCCCCC/C=C\CCCCCCCC(O)=O
MDL No. MFCD00064242
别名 (9Z)-9-十八烯酸 ;9-cis-Octadecenoic acid; 9Z-Octadecenoic acid; D 100; C18:1 (cis-9) Fatty acid; Octadecenoic acid (cis-9); Elaidoic acid; 9-Octadecenoic Acid; Oleate
运输蓝冰
InChI Key ZQPPMHVWECSIRJ-KTKRTIGZSA-N
Pubchem ID 445639
存储条件

In solvent -20°C:3-6个月-80°C:12个月
溶解方案

DMSO: 60 mg/mL(212.42 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(354.03 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

0.1 M NaOH: 100 mg/mL(354.03 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
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Tags: Oleic acid | 9-cis-Octadecenoic acid;9Z-Octadecenoic acid;D 100;C18:1 (cis-9) Fatty acid;Octadecenoic acid (cis-9);Elaidoic acid;9-Octadecenoic Acid;Oleate | (9Z)-9-十八烯酸 | Apoptosis Inducer | Apoptosis | Na+/K+ ATPase | AmBeed-信号通路专用抑制剂 | Oleic acid/油酸 纯度/质量文件 | Oleic acid/油酸 生物活性 | Oleic acid/油酸 临床数据 | Oleic acid/油酸 参考文献 | Oleic acid/油酸 实验方案 | Oleic acid/油酸 技术信息

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