Oleic acid

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Chemical Structure| 112-80-1 同义名 : (9Z)-9-十八烯酸 ;9-cis-Octadecenoic acid; 9Z-Octadecenoic acid; D 100; C18:1 (cis-9) Fatty acid; Octadecenoic acid (cis-9); Elaidoic acid; 9-Octadecenoic Acid; Oleate
CAS号 : 112-80-1
货号 : A387371
分子式 : C18H34O2
纯度 : 98%
分子量 : 282.46
MDL号 : MFCD00064242
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(212.42 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(354.03 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

0.1 M NaOH: 100 mg/mL(354.03 mM)，配合低频超声助溶
生物活性
描述 Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is also used as an activator of Na+/K+ ATPase.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02646202 Gastroesophageal Varices Phase 3 Recruiting December 2021 Egypt ... 展开 >> Tropical medicine dept.-Tanta university hospital Recruiting Tanta, Egypt Contact: Sherief Abd-Elsalam       Sherif_tropical@yahoo.com 收起 <<
NCT02049034 Type 2 Diabetes Phase 4 Completed - United Kingdom ... 展开 >> University of Surrey FHMS Diabetes and Metabolic Medicine Guildford, Surrey, United Kingdom, GU2 7WG 收起 <<
NCT01931826 Schistosomiasis Mansoni ... 展开 >> Portal Hypertension Upper Gastrointestinal Bleeding 收起 << Not Applicable Completed - Brazil ... 展开 >> Universidade Federal de Alagoas Maceio, Alagoas, Brazil, 57000000 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.54mL

0.71mL

0.35mL

17.70mL

3.54mL

1.77mL

35.40mL

7.08mL

3.54mL
参考文献

[1]Liu Z, Xiao Y, et al. Effects of oleic acid on cell proliferation through an integrin-linked kinase signaling pathway in 786-O renal cell carcinoma cells. Oncol Lett. 2013 Apr;5(4):1395-1399.

[2]Harvey KA, Walker CL, et al. Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. J Lipid Res. 2010 Dec;51(12):3470-80.

[3]Bueltmann M, Kong X, Mertens M, et al. Inhaled milrinone attenuates experimental acute lung injury. Intensive Care Med. 2009;35(1):171-178.

[4]Zuo T, Chen H, Xiang S, Hong J, Cao S, Weng L, Zhang L, Liu L, Li H, Zhu H, Liu Q. Cryptotanshinone-Loaded Cerasomes Formulation: In Vitro Drug Release, in Vivo Pharmacokinetics, and in Vivo Efficacy for Topical Therapy of Acne. ACS Omega. 2016 Dec 31;1(6):1326-1335. 

[5]Zhu Z, Chen T, Wang Z, Xue Y, Wu W, Wang Y, Du Q, Wu Y, Zeng Q, Jiang C, Shen C, Liu L, Zhu H, Liu Q. Integrated Proteomics and Metabolomics Link Acne to the Action Mechanisms of Cryptotanshinone Intervention. Front Pharmacol. 2021 Sep 1;12:700696.