Evaluate the potentiation of 5-FU cytotoxicity by NU3076 and dipyridamole. Results showed significant potentiation at high concentrations of 5-FU (30 µM and 100 µM).
Br J Cancer. 1999 Aug;80(11):1738-46
L1210 cells
10 µM
16 hours
Evaluate the potentiation of nolatrexed cytotoxicity by NU3076 and dipyridamole. Results showed that 1 µM NU3076 and 1 µM dipyridamole significantly reduced the LC90 by > threefold.
Br J Cancer. 1999 Aug;80(11):1738-46
WiDr B
2.70 µM
72 hours
To evaluate the anti-proliferative effects of Nolatrexed on WiDr B cells, IC50 value was 2.70 µM
Br J Cancer. 2007 Mar 12;96(5):769-75
WiDr T
2.30 µM
72 hours
To evaluate the anti-proliferative effects of Nolatrexed on WiDr T cells, IC50 value was 2.30 µM
Br J Cancer. 2007 Mar 12;96(5):769-75
Lovo li
2.10 µM
72 hours
To evaluate the anti-proliferative effects of Nolatrexed on Lovo li cells, IC50 value was 2.10 µM, showing higher sensitivity compared to Lovo 92 cells
Br J Cancer. 2007 Mar 12;96(5):769-75
Lovo 175X2
19.00 µM
72 hours
To evaluate the anti-proliferative effects of Nolatrexed on Lovo 175X2 cells, IC50 value was 19.00 µM, showing 3-fold resistance compared to Lovo 92 cells
Br J Cancer. 2007 Mar 12;96(5):769-75
Lovo 92
5.15 µM
72 hours
To evaluate the anti-proliferative effects of Nolatrexed on Lovo 92 cells, IC50 value was 5.15 µM
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