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Milrinone/米力农 {[allProObj[0].p_purity_real_show]}

货号：A218047 同义名： 米利酮 / Win 47203; WIN 47,203

Milrinone是一种磷酸二酯酶 3（PDE3）抑制剂，IC50 为 56 nM，能够通过增加细胞内环磷酸腺苷（cAMP）水平改善心室功能，并引起血管舒张。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Milrinone/米力农 化学结构 CAS号：78415-72-2
Milrinone/米力农 化学结构
CAS号：78415-72-2
Milrinone/米力农 3D分子结构
CAS号：78415-72-2
Milrinone/米力农 化学结构 CAS号：78415-72-2
Milrinone/米力农 3D分子结构 CAS号：78415-72-2
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Milrinone/米力农 纯度/质量文件 产品仅供科研

货号：A218047 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
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• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
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更多 >
产品名称 PDE ↓ PDE1 ↓ PDE10A ↓ PDE2 ↓ PDE3 ↓ PDE4 ↓ PDE5 ↓ PDE6 ↓ 其他靶点 纯度
Doxofylline ✔ 99+%
Deltarasin +++

PDEδ , Kd: 38 nM

 		95%
7-(2,3-Dihydroxypropyl)theophylline ✔ 98%
Aminophylline +

PDE, IC50: 0.12 mM

 		98+%
Anagrelide HCl ✔ 99%+
Irsogladine ✔ AChR,mAChR 99%
PF-8380 +++

Autotaxin, IC50: 2.8 nM

 		99%+
Dipyridamole ✔ 98%
Balipodect ++++

PDE10A, IC50: 0.3 nM

 		99%+
Luteolin +

PDE1, Ki: 15.0 μM

 		++

PDE2, Ki: 6.4 μM

 		+

PDE3, Ki: 13.9 μM

 		+

PDE4, Ki: 11.1 μM

 		+

PDE5, Ki: 9.5 μM

 		98%
Milrinone ++

PDE2, IC50: 5.2 μM

 		++

PDE3, IC50: 2.1 μM

 		ATPase 99%
Pimobendan ++

PDE3, IC50: 0.32 μM

 		98%
Cilostazol ++

PDE3, IC50: 0.2 μM

 		98%
Fenspiride HCl +

PDE3, pIC50: 3.44

 		+

PDE4, pIC50: 4.16

 		99% (HPLC)
(S)-(+)-Rolipram ++

PDE4, IC50: 0.75 μM

 		99% (HPLC)
Apremilast +++

PDE4, IC50: 74 nM

 		98%
GSK256066 ++++

PDE4B, IC50: 3.2 pM

 		98+%
Roflumilast ++++

PDE4A1, IC50: 0.7 nM

PDE4A4, IC50: 4.3 nM

 		99%
Rolipram +++

PDE4B, IC50: 130 nM

 		99%+
Cilomilast +++

LPDE4, IC50: 100 nM

HPDE4, IC50: 120 nM

 		99%
Avanafil ++++

PDE5, IC50: 1 nM

 		98%
Vardenafil HCl Trihydrate ++++

PDE5, IC50: 0.7 nM

 		98%
Tadalafil ++++

PDE5, IC50: 1.8 nM

 		98%
Icariin ++

PDE5, IC50: 0.432 μM

 		98%
Sildenafil ✔ +++

PDE6, IC50: 33 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Milrinone/米力农 生物活性

靶点

  • PDE2

    PDE2, IC50:5.2 μM

  • PDE3

    PDE3, IC50:2.1 μM
描述 Cyclic nucleotide phosphodiesterases (PDEs) from the human heart were separated into three isoforms, FI, FII and FIII. Milrinone has been proved to be a potent and selective inhibitor of human cardiac FIII PDE, a "low Km" enzyme for cyclic AMP (cAMP-PDE). The IC50 value for the inhibition of FIII PDE was 0.42 μM, while those of FI and FII PDEs, "high Km" enzymes, were 38 and 19 μM, respectively[3]. The concentration of milrinone that produced 50% relaxation of tracheal spirals constricted by carbachol was 3.6 × 10-5 M; The IC50 for milrinone for lung parenchymal strips contracted by histamine was 3.2 × 10-5 M; Milrinone relaxed pulmonary artery rings constricted by norepinephrine with an IC50 of 3.8 × 10-6 M[4]. Milrinone caused a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Furthermore, milrinone inhibited human platelet aggregation with an IC50 of 2 μM. It was a very potent cardiotonic agent, which concentration-dependently increased left ventricular developed pressure (LVDP) and contractility as well as cAMP in rabbit coronary smooth muscle cells[5]. In rabbit heart, partial inhibition of PDE4 by milrinone contributed to greater increases in cardiomyocyte cAMP and calcium levels[6]. In mongrel dogs underwent pulmonary artery catheterization, Milrinone led to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling[7].

Milrinone/米力农 细胞实验

Cell Line
Concentration Treated Time Description References
Mouse denuded oocytes 1.0 μM Inhibition of oocyte maturation J Clin Invest. 1998 Aug 1;102(3):532-7.
Mouse oocytes 1 µM 2 hours Maintain germinal vesicle stage arrest J Cell Biol. 2017 Dec 4;216(12):3949-3957.
Murine tracheal epithelial cells 13.7 µM 80 minutes To evaluate the effect of Milrinone on ciliary transport velocity in murine tracheal epithelial cells, results showed that Milrinone increased PTV in a dose-dependent manner with an EC50 of 13.7 µM. Cells. 2025 Feb 5;14(3):228.
Adult mouse cardiomyocytes 30 μM 24 hours To evaluate the effect of milrinone on hypoxia/reoxygenation or H2O2-induced cardiomyocyte apoptosis. Results showed that milrinone treatment significantly increased the apoptotic rate in both WT and TG cardiomyocytes. J Mol Cell Cardiol. 2013 Nov;64:11-9.
HT22CREluc cells 100 µM ~11 hours To investigate the effect of the PDE3-selective inhibitor milrinone on CRE-dependent transcriptional activity, results showed milrinone was effective at higher concentrations but two orders of magnitude less efficient than IBMX and rolipram. Int J Mol Sci. 2020 Nov 17;21(22):8658.
HEK-TSHR cells 1.0 mM Milrinone, as a PDE3-specific inhibitor, exposed persistent TSHR-mediated cAMP signaling Thyroid. 2013 Nov;23(11):1484-9.

Milrinone/米力农 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mice DF508 mutant mice Nasal perfusion 100 μM Single administration, lasting 4.5 minutes To evaluate the effect of milrinone and forskolin combination on the potential difference across nasal epithelium in DF508 mutant mice. Results showed that the combination significantly increased the potential difference, indicating partial restoration of CFTR-mediated electrolyte transport. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2604-8
Mice HDM-driven allergic airway inflammation model Intratracheal administration 10 μg 5 consecutive days Study the effect of milrinone on allergic airway inflammation JCI Insight. 2018 Jan 25;3(2):e94888.
Male ddY mice LPS-induced microvascular permeability change model Intraperitoneal injection 5 – 10 mg/kg Single dose, lasting 2 hours Milrinone significantly inhibited LPS-induced dye leakage and elevation of serum TNF-α levels Br J Pharmacol. 2001 May;133(2):237-42
Mice Murine tracheal model Intratracheal administration 13.7 µM Single administration, lasting 80 minutes To evaluate the effect of Milrinone on ciliary transport velocity in murine tracheae, results showed that Milrinone increased PTV via Ca2+ release from intracellular stores and depended on both PKA and PLC pathways. Cells. 2025 Feb 5;14(3):228.
Mice Transgenic mice with myocardial overexpression of PDE3A1 Intraperitoneal injection 10 mg/kg Single dose To evaluate the effect of milrinone on cardiac contractile function and heart rate. Results showed that milrinone treatment significantly attenuated the differences in cardiac contractile function and heart rate between TG and WT mice under ISO stimulation. J Mol Cell Cardiol. 2013 Nov;64:11-9.

Milrinone/米力农 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02606253 Heart Failure Phase 4 Active, not recruiting October 31, 2018 United States, Tennessee ... 展开 >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37204 收起 <<
NCT02884011 - Completed - United States, Illinois ... 展开 >> Rush Univeristy Medical Center Chicago, Illinois, United States, 60612 收起 <<
NCT02261506 Bacteremia Not Applicable Completed - Canada, Alberta ... 展开 >> Foothills Hospital Calgary, Alberta, Canada University of Alberta Hospital Edmonton, Alberta, Canada Canada, British Columbia Royal Columbian Hospital Vancouver, British Columbia, Canada St. Paul's Hospital Vancouver, British Columbia, Canada Canada, Manitoba St. Boniface Hospital Winnipeg, Manitoba, Canada Canada, Nova Scotia Queen Elizabeth II Hospital Halifax, Nova Scotia, Canada Canada, Ontario Kingston General Hospital Kingston, Ontario, Canada London Health Sciences Centre London, Ontario, Canada The Ottawa Hospital Ottawa, Ontario, Canada Sunnybrook Health Sciences Centre Toronto, Ontario, Canada, M4N3M5 Mount Sinai Hospital Toronto, Ontario, Canada St. Michael's Hospital Toronto, Ontario, Canada Toronto Western Hospital Toronto, Ontario, Canada Canada, Quebec CHUM Montreal, Quebec, Canada Université de Sherbrooke Sherbrooke, Quebec, Canada Canada Centre hospitalier affilié universitaire de Québec Quebec, Canada CSSS de Trois-Rivières Quebec, Canada 收起 <<

Milrinone/米力农 参考文献

[1]Cone J, Wang S, et al. Comparison of the effects of cilostazol and milrinone on intracellular cAMP levels and cellular function in platelets and cardiac cells. J Cardiovasc Pharmacol. 1999 Oct;34(4):497-504.

[2]Shipley JB, Tolman D, et al. Milrinone: basic and clinical pharmacology and acute and chronic management. Am J Med Sci. 1996 Jun;311(6):286-91.

[3]Ito M, Tanaka T, Saitoh M, Masuoka H, Nakano T, Hidaka H. Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine. Biochem Pharmacol. 1988 May 15;37(10):2041-4. doi: 10.1016/0006-2952(88)90554-0. PMID: 2837222.

[4]Rossing TH, Drazen JM. Effects of milrinone on contractile responses of guinea pig trachea, lung parenchyma and pulmonary artery. J Pharmacol Exp Ther. 1986 Sep;238(3):874-9. PMID: 3746666.

[5]Cone J, Wang S, Tandon N, Fong M, Sun B, Sakurai K, Yoshitake M, Kambayashi J, Liu Y. Comparison of the effects of cilostazol and milrinone on intracellular cAMP levels and cellular function in platelets and cardiac cells. J Cardiovasc Pharmacol. 1999 Oct;34(4):497-504. doi: 10.1097/00005344-199910000-00004. PMID: 10511123.

[6]Shakur Y, Fong M, Hensley J, Cone J, Movsesian MA, Kambayashi J, Yoshitake M, Liu Y. Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart. Cardiovasc Drugs Ther. 2002 Sep;16(5):417-27. doi: 10.1023/a:1022186402442. PMID: 12652111.

[7]Chen EP, Bittner HB, Davis RD Jr, Van Trigt P 3rd. Milrinone improves pulmonary hemodynamics and right ventricular function in chronic pulmonary hypertension. Ann Thorac Surg. 1997 Mar;63(3):814-21. doi: 10.1016/s0003-4975(97)00011-8. PMID: 9066407.

Milrinone/米力农 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.73mL

0.95mL

0.47mL

23.67mL

4.73mL

2.37mL

47.34mL

9.47mL

4.73mL

Milrinone/米力农 技术信息

CAS号78415-72-2
分子式C12H9N3O
分子量 211.22
SMILES Code N#CC1=CC(C2=CC=NC=C2)=C(C)NC1=O
MDL No. MFCD00133539
别名 米利酮 ;Win 47203; WIN 47,203; Milrinone, Primacor, Corotrop, Milrila, Win-47203
运输蓝冰
InChI Key PZRHRDRVRGEVNW-UHFFFAOYSA-N
Pubchem ID 4197
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry,2-8°C
溶解方案

DMSO: 50 mg/mL(236.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: Milrinone | 78415-72-2 | Win 47203 | Win47203 | Win-47203 | Phosphodiesterase (PDE) Inhibitor | Metabolic Enzyme/Protease | Phosphodiesterase (PDE) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Milrinone/米力农 纯度/质量文件 | Milrinone/米力农 亚型比较 | Milrinone/米力农 生物活性 | Milrinone/米力农 临床数据 | Milrinone/米力农 参考文献 | Milrinone/米力农 实验方案 | Milrinone/米力农 技术信息

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