Methylene blue is a synthetic basic dye used in chromoendoscopy to identify dysplasia, or pre-cancerous lesions. It also can stain cells and tissues in research.It also works as a soluble guanylyl cyclase inhibitor.
Methylene blue (Basic Blue 9) inhibits guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and NO synthase (NOS). It acts as a vasopressor and is commonly used as a medical dye. Methylene blue impacts the nitric oxide synthase/guanylate cyclase signaling pathway to modulate prepulse inhibition and is a REDOX cycling compound that can cross the blood-brain barrier. Additionally, it inhibits Tau aggregation and is known to reduce cerebral edema, attenuate microglial activation, and lessen neuroinflammation[1][2][3].
体内研究
Methylene blue (Basic Blue 9), administered at 50 and 100 mg/kg intraperitoneally once for 25 minutes in male NMRI mice, reduces the absence of prepulse inhibition[1].
Methylene blue (Basic Blue 9) administered at doses of 20 and 40 mg/kg orally each day for six months to CaMKIIα-tTA transactivator mice helps preserve cognitive function in mice that express full-length pro-aggregant human Tau[2].
Methylene blue (Basic Blue 9), administered intravenously at a dose of 2 mg/kg for one day to TBI-treated male BALB/c mice, decreases the levels of inflammatory factors[3].
体外研究
Methylene blue (Basic Blue 9) at a concentration of 4.5 μM in BV2 microglia alters the immune profile of LPS-activated BV2 microglia, reducing levels of CD14, IL-1β, TNF-α, and CCL2 mRNA[3].
United States, Texas
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Research Imaging Institute, The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229 收起 <<
United States, Texas
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Research Imaging Institute, The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229 收起 <<
Brachial Plexus Block
... 展开 >> Shoulder Surgery 收起 <<
Not Applicable
Recruiting
October 1, 2018
Brazil
... 展开 >> Federal University of Sao Paulo
Recruiting
Sao Paulo, Brazil, 04024002
Contact: Leonardo HC Ferraro, PhD +5511999516103 leohcferraro@yahoo.com.br 收起 <<
Brazil
... 展开 >> Universidade Federal Fluminense
Recruiting
Nova Friburgo, Rio De Janeiro, Brazil, 28625650
Contact: Livia Antunes, PhD 55219871519191 liviaazeredo@gmail.com
Contact: Leonardo Antunes, PhD 5521988911919 leonardoantunes@id.uff.br 收起 <<
United States, Pennsylvania
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University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
United States, Texas
University of Texas
Austin, Texas, United States, 78712
United States, Washington
University of Washington
Seattle, Washington, United States, 98195 收起 <<
Brazil
... 展开 >> Nove de Julho University
Not yet recruiting
São Paulo, Brazil, 01504-001
Contact: Anna Carolina Ratto T Horliana, Phd +551133859197 annacrth@gmail.com
Contact: Anna Carolina Ratto Tempestini Horliana, Phd +551133859197 annacrth@gmail.com 收起 <<
Brazil
... 展开 >> Centro de Medicina Reprodutiva Carlos Isaia Filho Ltda
Not yet recruiting
Porto Alegre, Rio Grande do Sul, Brazil
Contact: Carlos Isaia Filho, MD
UNISA
Not yet recruiting
Santo Amaro, São Paulo, Brazil
Contact: Lucia Hime, MD
Marcio Antonio Pereira Clinica de Endocrinologia
Not yet recruiting
São José dos Campos, São Paulo, Brazil
Contact: Marcio A. Pereira, MD
AFIP
Not yet recruiting
São Paulo, Brazil
Contact: Helena H. Campos, MD
Savmed Clinica Médica S/C Ltda.
Not yet recruiting
São Paulo, Brazil
Contact: Felício Savióli, MD
Sociedade de atendimento Cardiológico LTDA
Not yet recruiting
São Paulo, Brazil
Contact: Nabil Ghorayeb, MD
Principal Investigator: Patrícia Smith, MD
USP
Not yet recruiting
São Paulo, Brazil
Contact: Ceci M Carvalho Lopes, MD 收起 <<
United States, Louisiana
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University Medical Center
Lafayette, Louisiana, United States, 70506
LSU Interim Hospital
New Orleans, Louisiana, United States, 70112 收起 <<
United States, New York
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University of Rochester Medical Center
Recruiting
Rochester, New York, United States, 14642
Contact: Thomas H Foster, PhD 585-275-1347 Thomas_Foster@URMC.Rochester.edu
Contact: JoAnne McNamara, MSN 585-275-8849 JoAnne_McNamara@URMC.Rochester.edu
Principal Investigator: Thomas H Foster, PhD
Principal Investigator: Ashwani K Sharma, MD
Sub-Investigator: Adam S Fang, MD
Sub-Investigator: David L Waldman, MD, PhD
Sub-Investigator: Timothy M Baran, PhD
Sub-Investigator: Constantine G Haidaris, PhD 收起 <<
France
... 展开 >> Amiens University Hospital
Recruiting
Amiens, France
Contact: jean marc regimbeau, MD, PhD +33 3 22 66 83 00 regimbeau.jean-marc@chu-amiens.fr 收起 <<
Canada, Nova Scotia
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CDHA- QE II Health Sciences Centre
Halifax, Nova Scotia, Canada, B3H-2E2
Canada, Ontario
St. Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 3K7 收起 <<
Diseases of Oral Cavity Saliva... 展开 >>ry Glands and Jaws 收起 <<
Early Phase 1
Not yet recruiting
January 2021
United States, Texas
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University of Texas MD Anderson Cancer Center
Not yet recruiting
Houston, Texas, United States, 77030
Contact: Clinical Research Operations CR_Study_Registration@mdanderson.org 收起 <<
Belgium
... 展开 >> Universitair Ziekenhuis
Gent, Belgium, 9000
Greece
G. H. A. Evaggelismos
Athens, Greece, 10676
Spain
Complexo Hospitalario Universitario
Santiago de Compostela, La Coruña, Spain, 15706
United Kingdom
University Hospitals of Leicester NHS Trust
Leicester, United Kingdom, LE1 5WW 收起 <<
United States, Michigan
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Henry Ford Health System
Recruiting
Detroit, Michigan, United States, 48202
Contact: Michele Moyer
Principal Investigator: Richard Nowak, MD 收起 <<
United States, Texas
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Research Imaging Institute, The University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229 收起 <<
United States, Arizona
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Dr Michelle Young
Phoenix, Arizona, United States, 85012
Dr Francesco Ramirez
Scottsdale, Arizona, United States, 85259
United States, Colorado
Dr David Gatof
Lafayette, Colorado, United States, 80026
United States, Florida
Dr Michael Wallace
Jacksonville, Florida, United States, 32224
United States, Kansas
Dr Prateek Sharma
Kansas City, Kansas, United States, 66103
United States, Maryland
Dr Marcia Canto
Baltimore, Maryland, United States, 21287
United States, Minnesota
Dr David Bruining
Rochester, Minnesota, United States, 55905
Belgium
Dr Raf Bisschop
Leuven, Belgium
Canada, Ontario
Dr Norman Marcon
Toronto, Ontario, Canada, M5B 1W8
Germany
Dr Ralf Kiesslich
Wiesbaden, Germany
Italy
Dr Renato Cannizzaro
Aviano, Italy
Dr Cesare Hassan
Rome, Italy
Dr Alessandro Repici
Rozzano, Italy
Lithuania
Dr Limas Kupcinskas
Kaunas, Lithuania
Netherlands
Dr Evelien Dekker
Amsterdam, Netherlands
Dr Manoon Spander
Rotterdam, Netherlands
Dr Peter Siersema
Utrecht, Netherlands
United Kingdom
Dr James East
Oxford, United Kingdom
Dr Matthew Rutter
Stockton-on-Tees, United Kingdom 收起 <<
Korea, Republic of
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Seoul National University Bundang Hospital
Recruiting
Seongnam-si, Kyeongi-do, Korea, Republic of
Contact: Kyuseok Kim, MD +82-31-787-7572 dremkks@snubh.org
Seoul National University Hospital
Recruiting
Seoul, Korea, Republic of
Contact: Kyuseok Kim +82-31-787-7572 dremkks@snubh.org
SMG - SNU Boramae Medical Center
Recruiting
Seoul, Korea, Republic of
Contact: Kyuseok Kim +82-31-787-7572 dremkks@snubh.org 收起 <<
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