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/ Methoxsalen/花椒毒素

Methoxsalen/花椒毒素 {[allProObj[0].p_purity_real_show]}

货号：A372661 同义名： 甲氧沙林 / 8-Methoxypsoralen; Xanthotoxin

Methoxsalen是一种呋喃香豆素，是传统埃及药用植物Ammi majus L.的活性化合物，该植物的果实/汁液多年来已用于治疗白癜风或过度增生性皮肤疾病如牛皮癣。它是一种强效的CYP（细胞色素P-450）自杀性抑制剂，用于治疗白癜风、湿疹、银屑病和某些皮肤淋巴瘤，通常与阳光照射结合使用。

Methoxsalen/花椒毒素 化学结构 CAS号：298-81-7
Methoxsalen/花椒毒素 化学结构
CAS号：298-81-7
Methoxsalen/花椒毒素 3D分子结构
CAS号：298-81-7
Methoxsalen/花椒毒素 化学结构 CAS号：298-81-7
Methoxsalen/花椒毒素 3D分子结构 CAS号：298-81-7
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Methoxsalen/花椒毒素 纯度/质量文件 产品仅供科研

货号：A372661 标准纯度： {[allProObj[0].p_purity_real_show]}
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Methoxsalen/花椒毒素 生物活性

描述 Methoxsalen is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. Methoxsalen pretreatment prolonged the duration of nicotine-induced antinociception and hypothermia (15mg/kg, po) for periods up to 6- and 24-hr postnicotine administration, respectively[3]. Using the guinea pig as an experimental model, UV-A (long-wave UV) irradiation given immediately after the topical application of methoxsalen resulted in the notable suppression of tritiated thymidine incorporation into epidermal basal cells[4]. Oral methoxsalen when used in the higher dose followed by sun exposure is an effective treatment for psoriasis[5]. Administration of methoxsalen (50 mumol X kg-1 i.p.) increased 4-fold the hexobarbital sleeping time in rats. Methoxsalen (25-1000 microM) decreased cytochrome P-450 in vitro, in the presence of EDTA; this effect required NADPH and oxygen, was decreased by piperonyl butoxide and was increased by phenobarbital pretreatment. Similarly, administration of methoxsalen (125 mumol X kg-1 i.p.) decreased cytochrome P-450 and monooxygenase activities in vivo; the decrease in cytochrome P-450 was enhanced by phenobarbital pretreatment and was prevented by piperonyl butoxide[6].

Methoxsalen/花椒毒素 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00045305 - Completed - -
NCT00724061 Lymphoma Not Applicable Terminated(Closed early due to... 展开 >> poor accrual.) 收起 << - United States, Illinois ... 展开 >> Robert H. Lurie Comprehensive Cancer Center at Northwestern University Chicago, Illinois, United States, 60611-3013 收起 <<
NCT00045305 Leukemia Myel... 展开 >>odysplastic Syndromes Myelodysplastic/Myeloproliferative Neoplasms 收起 << Phase 2 Completed - United States, Arizona ... 展开 >> Mayo Clinic Scottsdale Scottsdale, Arizona, United States, 85259-5499 United States, Florida Mayo Clinic - Jacksonville Jacksonville, Florida, United States, 32224 United States, Massachusetts Tufts-NEMC Cancer Center Boston, Massachusetts, United States, 02111 United States, Minnesota Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 United States, Ohio Jewish Hospital Cancer Center Cincinnati, Ohio, United States, 45236 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 收起 <<

Methoxsalen/花椒毒素 参考文献

[1]Zhang W, Kilicarslan T, et al. Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Drug Metab Dispos. 2001 Jun;29(6):897-902.

[2]Maenpaa J, Juvonen R, et al Metabolic interactions of methoxsalen and coumarin in humans and mice. Biochem Pharmacol. 1994 Oct 7;48(7):1363-9.

[3]Alsharari SD, Siu EC, Tyndale RF, Damaj MI. Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor. Nicotine Tob Res. 2014 Jan;16(1):18-25

[4]Danno K, Toda K, Ishida H, Horio T. Topical methoxsalen followed immediately by long-wave UV irradiation. A preliminary report on the treatment of psoriasis. Arch Dermatol. 1982 Jul;118(7):471-3

[5]Parrish JA, White AD, Kingsbury T, Zahar M, Fitzpatrick TB. Photochemotherapy of psoriasis using methoxsalen and sunlight. A controlled study. Arch Dermatol. 1977 Nov;113(11):1529-32

[6]Fouin-Fortunet H, Tinel M, Descatoire V, Letteron P, Larrey D, Geneve J, Pessayre D. Inactivation of cytochrome P-450 by the drug methoxsalen. J Pharmacol Exp Ther. 1986 Jan;236(1):237-47

Methoxsalen/花椒毒素 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.63mL

0.93mL

0.46mL

23.13mL

4.63mL

2.31mL

46.26mL

9.25mL

4.63mL

Methoxsalen/花椒毒素 技术信息

CAS号298-81-7
分子式C12H8O4
分子量 216.19
SMILES Code O=C1C=CC2=C(O1)C(OC)=C(OC=C3)C3=C2
MDL No. MFCD00005009
别名 甲氧沙林 ;8-Methoxypsoralen; Xanthotoxin; Oxsorale; NCI-C55903; 8-MOP
运输蓝冰
InChI Key QXKHYNVANLEOEG-UHFFFAOYSA-N
Pubchem ID 4114
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry, room temperature
溶解方案

DMSO: 50 mg/mL(231.28 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二

Tags: Methoxsalen | 8-Methoxypsoralen;Xanthotoxin;Oxsorale;Methoxypsoralen. NCI-C55903;8-MOP | 甲氧沙林 | Other Compounds | P450 | AmBeed-信号通路专用抑制剂 | Methoxsalen/花椒毒素 纯度/质量文件 | Methoxsalen/花椒毒素 生物活性 | Methoxsalen/花椒毒素 临床数据 | Methoxsalen/花椒毒素 参考文献 | Methoxsalen/花椒毒素 实验方案 | Methoxsalen/花椒毒素 技术信息

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