MPP+ iodide是神经毒素 MPTP 的一种有毒代谢物，可选择性破坏黑质多巴胺能神经元，影响呼吸链复合体 I ，对线粒体发挥神经毒性作用，在动物模型中引起帕金森病症状。
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USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
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Accessible (Haz class 3, 4, 5 or 8), International
MPP+ significantly increased SH-SY5Y cell mortality, and both 100 nM P4 and 02-0 were effective in reducing MPP+-induced cell death.
Front Endocrinol (Lausanne). 2023 Mar 10;14:1125962.
C2C12 cells
500 µM
18 h
To investigate the effect of MPP+ on ITGA7 and α-syn expression in C2C12 cells, results showed decreased ITGA7 expression and increased α-syn expression.
Int J Mol Sci. 2022 May 18;23(10):5646.
SH-SY5Y cells
2 mM
48 h
To investigate MPP+-induced cell death, 1ACTA significantly reduced the number of PI-positive cells, indicating its protective effect against MPP+-induced cell death.
ACS Chem Biol. 2024 Dec 20;19(12):2429-2437.
HEK293T cells
10 nM
40 min
Measure MPP+ uptake activity of OCT1 CS and mutants in HEK293T cells
Nat Struct Mol Biol. 2023 Jul;30(7):1001-1011.
Xenopus laevis oocytes
100 nM
1 h
Measure MPP+ uptake activity of OCT1 CS and mutants in Xenopus laevis oocytes
Nat Struct Mol Biol. 2023 Jul;30(7):1001-1011.
SH-SY5Y cells
0.1 mM
24 h
To investigate the effect of N-hcy on the antioxidant activity of DJ-1, the results showed that HTL treatment attenuated the protective effect of DJ-1 against MPP+-induced cytotoxicity.
Aging Cell. 2024 May;23(5):e14124.
HEK293 cells
1 mM
24 h
To investigate whether DJ-1 undergoes N-hcy, the results showed that HTL induced N-hcy of DJ-1.
Aging Cell. 2024 May;23(5):e14124.
PC12 cells
1 mM
24 h
To evaluate the neurotoxic effects of MPP+ on PC12 cells, the results showed that MPP+ significantly reduced cell viability.
Sci Rep. 2017 Dec 5;7(1):16977.
PC12 cells
0.01, 0.1, 1, 10 µM
24 h
To evaluate the inhibitory effects of curcumin and cyclocurcumin on MPP+-induced cytotoxicity in PC12 cells, the results showed that both curcumin and cyclocurcumin significantly increased cell viability, with cyclocurcumin being more effective.
Sci Rep. 2017 Dec 5;7(1):16977.
MPP+ iodide 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
Chronic MPP+ infusion model
Intracerebroventricular infusion
75 μg/day
Daily for 28 days
To investigate the neuroprotective effects of captopril against MPP+-induced neurodegeneration, results showed that captopril significantly reduced the loss of nigral dopamine neurons.
Exp Neurol. 2013 Dec;250:376-83
Mice
MPTP-induced Parkinson's disease model
Intraperitoneal injection
20 mg/kg
Once daily for 4 weeks
To investigate the effect of MPTP on ITGA7 and α-syn expression in the mouse model, results showed decreased ITGA7 expression and increased α-syn expression.
Int J Mol Sci. 2022 May 18;23(10):5646.
Rat
Chronic PD model
Left cerebral ventricle infusion
75 μg/day
28 days
MPP+ infusion produces a progressive loss of nigral dopamine neurons, and caffeine treatment can prevent the loss of neurons even when introduced after the onset of the neurodegenerative process.
Exp Neurol. 2012 Apr;234(2):482-7
C57BL/6J mice
MPTP-induced Parkinson's disease model
Intraperitoneal injection
30 mg/kg
Once daily for five consecutive days
To investigate the effect of Met administration on MPTP-induced Parkinson's disease pathology, the results showed that Met administration exacerbated MPTP-induced neurodegeneration and motor dysfunction.
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