MMAF-OMe
{[allProObj[0].p_purity_real_show]}
货号：A700623
同义名：
Monomethyl auristatin F methyl ester
MMAF-OMe 是一种合成的抗肿瘤药物，抑制微管蛋白聚合，破坏细胞有丝分裂纺锤体，导致G2/M期停滞和凋亡。MMAF-OMe作为抗体偶联药物（ADC）的细胞毒性载荷（如ABT-414），靶向递送至肿瘤细胞。
MMAF-OMe 化学结构
MMAF-OMe 3D分子结构
规格
价格
会员价
库存
数量
{[ item.pr_size ]}
{[ getRatePriceInt(item.pr_rmb, 1,1) ]}
{[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]}
{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}
{[ getRatePriceInt(item.pr_rmb, 1,1) ]}
{[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]}
{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}
{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}
{[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]}
{[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]}
{[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]}
现货
1周
咨询
-
+
MMAF-OMe 纯度/质量文件 产品仅供科研
货号：A700623
标准纯度：
{[allProObj[0].p_purity_real_show]}
产品说明书
全球学术期刊中引用的产品
• Nature , 2025, 645, 793-800. Ambeed. A201204 ,
A444152 ,
A344107 ,
A952055
]
• Cell , 2025. Ambeed. A122167
]
• Science , 2025, 387(6729): eadp5637. Ambeed. • Sig. Transduct. Target. Ther. , 2025, 10, 257. Ambeed. A104916
]
• Nat. Nanotechnol. , 2025. Ambeed. A1216705 ,
A522597 ,
A125401 ,
A1355641
]
更多 >
MMAF-OMe 质控信息
MMAF-OMe 生物活性
描述
MMAF-Ome is a methoxyl analogue of MMAF, used in antibody-drug conjugates (ADCs) as the antimitotic agent part[3] [4] [3]
MMAF-OMe 动物研究
Dose
Rat: 5 mg/kg[3] [3] [1]
Administration
i.v., p.o.
MMAF-OMe 参考文献
[1] Doronina SO, Mendelsohn BA, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.
[2] Chen H, Lin Z, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). pii: E1281.
[3] Doronina SO, Mendelsohn BA, Bovee TD, Cerveny CG, Alley SC, Meyer DL, Oflazoglu E, Toki BE, Sanderson RJ, Zabinski RF, Wahl AF, Senter PD. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24. doi: 10.1021/bc0502917. PMID: 16417259.
[4] Chen H, Lin Z, Arnst KE, Miller DD, Li W. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8):1281. doi: 10.3390/molecules22081281. PMID: 28763044; PMCID: PMC6152078.
展开
MMAF-OMe 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.34mL
0.27mL
0.13mL
6.70mL
1.34mL
0.67mL
13.41mL
2.68mL
1.34mL
MMAF-OMe 技术信息
搜索
